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However, concomitant Drug\u2010Induced Liver Injury and Drug\u2010Induced Skin Injury are uncommon, not well characterized and appear to be caused by a limited number of drugs. These are often associated with immuno\u2010allergic or hypersensitivity features such as fever, skin rash, blisters or peeling of skin, eosinophilia, lymphadenopathy and mucositis. Liver injury can range from asymptomatic elevation of liver biochemical tests to severe hepatitis and acute liver failure needing liver transplantation. Severe cutaneous adverse reaction, particularly drug reaction with eosinophilia and systemic symptoms is commonly associated with internal organ involvement, the liver being the most frequently involved in approximately 90% of the cases. In Stevens\u2010Johnson Syndrome\/Toxic Epidermal Necrolysis, abnormalities in liver biochemistry tests are common but severe liver disease is rare. There is a strong association of Human Leukocyte Antigen genotype with both drug reaction with eosinophilia and systemic symptoms and Stevens\u2010Johnson Syndrome\/Toxic Epidermal Necrolysis. It is likely that the delayed immune\u2010mediated reaction triggering skin reaction is also responsible for hepatitis. Drug\u2010specific lymphocytes are found in the organs involved and also in circulating blood, which along with the cytokines and chemokines play a role in pathogenesis. Anti\u2010epileptic drugs, allopurinol, sulfonamides, antibiotics and nevirapine are the top five causes of concomitant liver and skin injury. This review will focus on drug and host factors causing concomitant Drug\u2010Induced Skin Injury and Drug\u2010Induced Liver Injury and discuss the characteristics of liver involvement in patients with severe cutaneous adverse reaction.<\/jats:p>","DOI":"10.1111\/liv.14004","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T07:04:35Z","timestamp":1543993475000},"page":"802-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Drug\u2010induced liver injury with skin reactions: Drugs and host risk factors, clinical phenotypes and prognosis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3593-3746","authenticated-orcid":false,"given":"Harshad","family":"Devarbhavi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology St. John\u2019s Medical College Hospital Bangalore 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