{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:13:48Z","timestamp":1793060028098,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Increasing numbers of autochthonous hepatitis E virus infections have been reported in Europe. Chronic infections have been shown in immune\u2010compromised patients after solid organ transplantation. Hepatitis E virus might be a possible trigger for autoimmune hepatitis and might cause disease flares or relapses in the further course of disease. Aim of this study was to investigate the presence of hepatitis E virus antibodies and hepatitis E virus RNA, and to analyse their impact on immunosuppressive treatment in patients with autoimmune hepatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sera from 92 autoimmune hepatitis patients (73\/79.3% female, age: 42.2\u00a0\u00b1\u00a016.3\u00a0years [mean\u00a0\u00b1\u00a0SD]) were tested. Patients were scored according to the simplified and revised scoring systems of the International Autoimmune Hepatitis Group. The prevalence of anti\u2010 hepatitis E virus antibodies (Beijing Wantai Biological Pharmacy Enterprises Co., Ltd, Beijing, China) and hepatitis E virus RNA was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>19\/20.7% autoimmune hepatitis patients tested positive for hepatitis E virus\u2010IgG, which was higher than in previous reports of healthy Austrian individuals (12.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.031); hepatitis E virus RNA was not detectable in any patient. Anti\u2010hepatitis E virus positive patients were older (49.5\u00a0\u00b1\u00a09.5 vs 40.4\u00a0\u00b1\u00a017.2\u00a0years [mean\u00a0\u00b1\u00a0SD], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.033) but did not differ in laboratory findings at diagnosis (AST: 14.6 [1.3\u201070.6] vs 9.5 [0.7\u201062.7]\u00a0\u00d7\u00a0ULN [median\/range]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.387, alanine aminotransferase: 18.3 [1.6\u201062.7] vs. 12.9 [0.8\u201062.6]\u00a0\u00d7\u00a0ULN; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.511; IgG: 1.4 [1.0\u20102.5] vs 1.3 [0.6\u20103.8]\u00a0g\/dL\u00a0\u00d7\u00a0ULN; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.278) nor in alanine aminotransferase levels after six months (0.7 [0.5\u20102.4] vs 1.0\u00a0U\/L\u00a0\u00d7\u00a0ULN [0.1\u201022.4]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.077).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No chronic hepatitis E virus infection was observed in our cohort of autoimmune hepatitis patients. Anti\u2010 hepatitis E virus\u2010IgG positive patients were older and the seroprevalence was nearly twice as high as reported previously in healthy Austrian individuals, suggesting that hepatitis E virus\u2010infection might act as trigger for the development of autoimmune hepatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14005","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T21:08:16Z","timestamp":1542316096000},"page":"640-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["High seroprevalence of anti\u2010Hepatitis E antibodies in Austrian patients with autoimmune hepatitis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6341-1275","authenticated-orcid":false,"given":"Michael","family":"Eder","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Division of Nephrology and Dialysis, Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Strassl","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis, Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Division of Clinical Virology, Department of Laboratory Medicine Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0785-9710","authenticated-orcid":false,"given":"Sandra","family":"Beinhardt","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Medizinische Abteilung \u2010 Gastroenterologie und Hepatologie Universit\u00e4tsklinikum St. P\u00f6lten   St. P\u00f6lten Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Friedrich","family":"St\u00e4ttermayer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-7662","authenticated-orcid":false,"given":"Karin","family":"Kozbial","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heimo","family":"Lagler","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Department of Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidemarie","family":"Holzmann","sequence":"additional","affiliation":[{"name":"Department of Virology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Hofer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Department of Internal Medicine I Klinikum Wels\u2010Grieskirchen Wels 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