{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:31:37Z","timestamp":1791304297044,"version":"4.3.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institute of Liver and Biliary Sciences"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Th17 cells mediated immune response is important in chronic hepatitis B (<jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>) infection and inflammation associated diseases; however, little is known about their immunopathogenic role in acute\u2010on\u2010chronic liver failure (<jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>). Interleukin\u201023 receptor (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023R) is essential for the generation of pathogenic Th17 cells; therefore, we aimed to evaluate <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023R expression and its correlation with disease severity in <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010two patients with <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> and alcohol\u2010related), thirty\u2010two with <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> and twenty healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) were studied. Circulating and intrahepatic profile of Th17 cells and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023R was investigated. Association of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023R with disease severity was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Circulating Th17 cells were significantly increased in both <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) than <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. Percentage of Th17 cells was higher in liver than peripheral blood of <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). Expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023R was immensely up\u2010regulated on Th17 cells of <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> patients. Importantly, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023R not only correlated with the increased percentage of Th17 cells but also had significant association with inflammation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and clinical disease severity indices including Child\u2010Turcotte\u2010Pugh (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and Model for End\u2010Stage Liver Disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) scores. The <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> non\u2010survivors showed higher <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023R expression (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Transcription factor retinoic acid receptor\u2010related orphan nuclear receptor gamma\u2010t (<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>\u2010\u03b3t) was also high in circulation and in liver of <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> patients and it positively correlated with <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). Surface receptors, including <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>6, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017R and pro\u2010inflammatory cytokines <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022, <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>8 and <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> were highly augmented in <jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content> patients express high <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023R on Th17 cells which induces inflammation and strongly correlates with liver disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14015","type":"journal-article","created":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T13:43:27Z","timestamp":1543758207000},"page":"1062-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Increased interleukin\u201023 receptor (<scp>IL<\/scp>\u201023R) expression is associated with disease severity in acute\u2010on\u2010chronic liver failure"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-6884","authenticated-orcid":false,"given":"Arshi","family":"Khanam","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Medicine Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6109-0033","authenticated-orcid":false,"given":"Nirupma","family":"Trehanpati","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Medicine Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-5610","authenticated-orcid":false,"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Medicine Institute of Liver and Biliary Sciences New Delhi India"},{"name":"Department of Hepatology Institute of Liver and Biliary Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.12.8391"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2013.58"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05505"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.09.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2027"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23273"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06782.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.110061"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1000030"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06154.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i38.10721"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01561.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.12.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003410"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2012.12.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0891-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i26.8558"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.08.014"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2016.10.005"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.91663"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6090081"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/PTT.S98893"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000442014.52661.20"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9106-x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12415"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.090142"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00540.2013"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017160"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110462"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.04.004"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.84"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026342"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(14)70015-8"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04471.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082030"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26916"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-102"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.4197"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200411000-00017"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.14015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.14015","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T08:17:40Z","timestamp":1694333860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.14015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,14]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/liv.14015"],"URL":"https:\/\/doi.org\/10.1111\/liv.14015","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,14]]},"assertion":[{"value":"2018-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}