{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:06:33Z","timestamp":1784210793291,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI 12\/00330"],"award-info":[{"award-number":["PI 12\/00330"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI 16\/00043"],"award-info":[{"award-number":["PI 16\/00043"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several lines of evidence indicate that decompensated cirrhosis is characterized by the presence of systemic inflammation. Hepatorenal syndrome (HRS\u2010AKI) is a unique type of renal failure that occurs at late stages of cirrhosis. However, confirmation of the presence and significance of such inflammatory response in HRS\u2010AKI is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim and Methods<\/jats:title>\n                    <jats:p>To characterize the systemic inflammatory response, as estimated by measuring a large number of cytokines, in 161 patients hospitalized for an acute decompensation of cirrhosis: 44 patients without acute kidney injury (AKI), 63 patients with hypovolaemia\u2010induced AKI and 58 patients with HRS\u2010AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HRS\u2010AKI was characterized by an altered cytokine profile compared to the other two groups, particularly IL\u20106, IL\u20108, TNF\u2010\u03b1, VCAM\u20101, fractalkine and MIP\u20101\u03b1. The inflammatory response was not related to presence of bacterial infection, concomitant acute\u2010on\u2010chronic liver failure or severity of renal dysfunction. Patients who responded to terlipressin and albumin had only a decrease in TNF\u2010\u03b1 and RANTES after treatment without changes in other cytokines. Interestingly, patients with persistent HRS\u2010AKI had higher levels of IP\u201010 and VCAM\u20101 compared to those with resolution of HRS\u2010AKI. VCAM\u20101 was also an independent predictor of 3\u2010month mortality. A systems biology analysis approach showed that the inflammatory status of HRS\u2010AKI was similar to that of chronic nonhepatic inflammatory conditions, such as lupus erythematosus or inflammatory bowel disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hepatorenal syndrome is characterized by a marked systemic inflammatory state, reminiscent of that of nonhepatic inflammatory diseases, that correlates with patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.14037","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T17:12:19Z","timestamp":1546276339000},"page":"1246-1255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-8345","authenticated-orcid":false,"given":"Cristina","family":"Sol\u00e9","sequence":"first","affiliation":[{"name":"Liver Unit Hospital Cl\u00ednic de Barcelona, University of Barcelona Barcelona Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEReHD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Sol\u00e0","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Cl\u00ednic de Barcelona, University of Barcelona Barcelona Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEReHD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Huelin","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Cl\u00ednic de Barcelona, University of Barcelona Barcelona Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEReHD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Carol","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Faculty of Medicine and Health Sciences University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Moreira","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Cl\u00ednic de Barcelona, University of Barcelona Barcelona 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