{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:04:31Z","timestamp":1769724271173,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tenofovir disoproxil fumarate (TDF) is active against both HBV and HIV. Whether the introduction of TDF\u2010containing combination antiretroviral therapy (cART) has improved the outcome of HIV\/HBV\u2010coinfected patients remains unclear in areas of higher HBV endemicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed medical records of newly diagnosed antiretroviral\u2010na\u00efve HIV\u2010infected patients between 2007 and 2015. Four groups of patients were defined, according to the HBV status and availability of TDF for HIV treatment in Taiwan in 2011. The primary outcome was all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 9\u2010year study period, 1,723 HIV\u2010infected patients were included, with a median age of 31\u00a0years and baseline CD4 count of 273 cells per \u03bcL. The HBV seroprevalence had declined from 18.1% (125\/692) in the pre\u2010TDF era to 10.1% (104\/1031) in the post\u2010TDF era. The respective mortality rate for HIV\/HBV\u2010coinfected and HIV\u2010monoinfected patients in the pre\u2010TDF era was 23.2 (95% CI, 12.5\u201043.1) and 9.6 (95% CI, 6.1\u201015.0) deaths per 1000 person\u2010years of follow\u2010up [PYFU], and the respective mortality rate in the post\u2010TDF era was 15.7 (95% CI, 7.0\u201034.8) and 8.0 (95% CI, 5.5\u201011.6) deaths per 1000 PYFU. The adjusted hazard ratio for mortality in multivariate Cox proportional\u2010hazards regression analysis among HIV\/HBV\u2010coinfected patients compared to HIV\u2010monoinfected patients was 2.79 (95% CI, 1.25\u20106.22) in pre\u2010TDF era and 1.11 (95% CI, 0.45\u20102.72) in post\u2010TDF era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this country of high HBV endemicity, the adverse impact of chronic HBV infection on the survival observed in the pre\u2010TDF era has significantly diminished among HIV\/HBV\u2010coinfected patients compared to HIV\u2010monoinfected patients in the era of TDF\u2010containing cART.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14059","type":"journal-article","created":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T11:30:15Z","timestamp":1549193415000},"page":"1408-1417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Impact of antiretroviral therapy containing tenofovir disoproxil fumarate on the survival of patients with HBV and HIV coinfection"],"prefix":"10.1111","volume":"39","author":[{"given":"Wan\u2010Chen","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ting","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang\u2010Da","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Yun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chung","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Shan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital Hsin\u2010Chu Branch Hsin\u2010Chu Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristine","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan\u2010Yin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine National Taiwan University Hospital Jin\u2010Shan Branch New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Hsin\u2010Chu Branch Hsin\u2010Chu Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan\u2010Jhou","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin 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