{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:20:27Z","timestamp":1774898427438,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>The prognosis of biliary tract cancer (BTC) is poor. Standard treatment for advanced BTC is a chemotherapy (CT) with gemcitabine and cisplatin. Phase III evidence for a second\u2010line (2L) CT is lacking. We aimed to investigate the feasibility of a 2L CT, to estimate the outcome and to identify prognostic markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients of our institution with advanced BTC between 2000 and 2015 receiving CT were included. Data were analysed in univariate and multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three\u2010hundred and fifteen and 144 patients (45.7%) received first\u2010line (1L) and 2L CT respectively. The OS of patients receiving 2L CT was 16.67 and 9.9\u00a0months from the beginning of 1L and 2L CT respectively. The overall response rate and the disease control rate after 3\u00a0months were 9.7% and 33.6% respectively. Adverse events of grade 3 or more were observed in 26.1%. One patient died of gemcitabine\u2010related haemolytic uraemic syndrome. Age of more than 70\u00a0years was not associated with a poor outcome. In multivariate analysis, CEA levels of &gt;3\u00a0\u00b5g\/L (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004, hazard ratio [HR] 1.89, 95% CI 1.22, 2.91), cholinesterase (CHE) levels of &lt;5\u00a0kU\/L (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001, HR 2.11, 95% CI 1.34, 3.31) and leukocytosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001, HR 2.90, 95% CI 1.51, 5.56) were associated with poor survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite a relevant toxicity, our data suggest that 2L CT may be feasible in fit BTC patients. CEA elevation, leukocytosis and low CHE levels are unfavourable prognostic markers. Results from prospective randomized trials are urgently awaited.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14063","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T09:30:09Z","timestamp":1549359009000},"page":"914-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Second\u2010line chemotherapy in biliary tract cancer: Outcome and prognostic factors"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4687-3582","authenticated-orcid":false,"given":"Nora","family":"Schweitzer","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School Hannover Germany"},{"name":"Department of Internal Medicine I University Hospital Halle (Saale) Halle (Saale) 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