{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:35:14Z","timestamp":1790883314603,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000190","name":"University of Alberta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201506295035"],"award-info":[{"award-number":["201506295035"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31702123"],"award-info":[{"award-number":["31702123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Cirrhosis is associated with dysbiosis, but its functional consequences are still largely unknown. Short\u2010chain fatty acids (SCFAs) account for physiological interactions between the gut microbiota and host. Our aim was to assess the impact of cirrhotic dysbiosis on the production of SCFAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen patients with cirrhosis and 17 controls were selected. Microbiota composition in faecal samples was assessed by next\u2010generation 16S rRNA gene sequencing. SCFAs were measured with GC\u2010MS in faecal samples and after in vitro batch fermentations using arabinoxylan, resistant starch, pectin, and lactulose as substrates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 17 cirrhotic patients (mean age 58, eight males), six, nine and two were, respectively, Child\u2010Pugh class A, B and C. Eleven patients were on oral antibiotics, 11 on lactulose and 13 on proton pump inhibitors. Cirrhotic patients showed marked differences in the composition and diversity of gut microbiome when compared to controls, that were more pronounced with increased severity. Stool samples from cirrhotic patients showed lower SCFAs content and reduced capacity to produce SCFAs in batch fermentations, with butyrate production being the most abnormal. These functional aberrancies were more pronounced with greater liver disease severity. Abundance of <jats:italic>Ruminococcus faecis<\/jats:italic> (in family Ruminococcaceae), <jats:italic>Faecalicatena fissicatena<\/jats:italic> and <jats:italic>Fusicatenibacter saccharivorans<\/jats:italic> (in family Lachnospiraceae) was positively correlated with the SCFAs production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cirrhotic dysbiosis is associated with a decreased capacity to ferment non\u2010digestible carbohydrates into SCFAs, especially into butyrate. These functional abnormalities are more pronounced as disease progresses. These results might inform the design of gut\u2010targeted therapies for cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14106","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T07:56:30Z","timestamp":1553759790000},"page":"1437-1447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["Faecal microbiota from patients with cirrhosis has a low capacity to ferment non\u2010digestible carbohydrates into short\u2010chain fatty acids"],"prefix":"10.1111","volume":"39","author":[{"given":"Mingliang","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Agricultural, Food and Nutritional Science University of Alberta Edmonton Alberta Canada"},{"name":"College of Animal Sciences Zhejiang University Hangzhou PR China"},{"name":"School of Life Sciences Northwestern Polytechnical University Xi\u2019an PR 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