{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:14:42Z","timestamp":1790694882209,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>The role of portal vein thrombosis (PVT) in the natural history of cirrhosis is controversial. There are few prospective studies validating risk factors for development of PVT. We analysed the incidence, factors associated with PVT development and its influence on cirrhosis decompensations and orthotopic liver transplant (OLT)\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective observational study between January 2014 and March 2019, 445 consecutive patients with chronic liver disease were screened and finally 241 with cirrhosis included. Factors associated with PVT development and its influence on cirrhosis decompensations and OLT\u2010free survival by time dependent covariate coding were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Majority of patients belonged to Child\u2010Pugh class A 184 (76.3%) and the average MELD score was 10\u00a0\u00b1\u00a05. Previous cirrhosis decompensations occurred in 125 (52.1%), 63 (26.1%) were on NSBB and 59 (27.2%) had undergone banding for bleeding prophylaxis. Median follow\u2010up was 29 (1\u201058)\u00a0months. Cumulative incidence of PVT was 3.7% and 7.6% at 1 and 3\u00a0years. Previous decompensation of cirrhosis and low platelet counts but not NSBB independently predicted the development of PVT. During follow\u2010up, 82\/236 (34.7%) patients developed cirrhosis decompensations. OLT\u2010free survival was 100% and 82.8% at 3\u00a0years, with and without PVT respectively. MELD score, but not PVT, independently predicted cirrhosis decompensations (HR 1.14; 95%CI:1.09\u20101.19) and OLT\u2010free survival (HR 1.16;95%CI:1.11\u20101.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Previous decompensations of cirrhosis and thrombocytopenia predict PVT development in cirrhosis suggesting a pathophysiologic role for severity of portal hypertension. PVT development did not independently predict cirrhosis decompensations or lower OLT\u2010free survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14121","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T15:51:39Z","timestamp":1556207499000},"page":"1459-1467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Incidence, predictive factors and clinical significance of development of portal vein thrombosis in cirrhosis: A prospective study"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7169-544X","authenticated-orcid":false,"given":"Carlos","family":"Noronha Ferreira","sequence":"first","affiliation":[{"name":"Servi\u00e7o De Gastrenterologia e Hepatologia Hospital De Santa Maria \u2010 Centro Hospitalar Lisboa Norte Lisboa Portugal"},{"name":"Faculdade de Medicina Cl\u00ednica Universit\u00e1ria de Gastrenterologia, Universidade de Lisboa 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