{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:18Z","timestamp":1787015718155,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control & Prevention","doi-asserted-by":"publisher","award":["2019-ER5102-00"],"award-info":[{"award-number":["2019-ER5102-00"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The modified PAGE\u2010B (mPAGE\u2010B) score comprising age, gender, platelet count and albumin was recently proposed to predict hepatocellular carcinoma (HCC) risk among chronic hepatitis B (CHB) patients undergoing antivirals. Here, in the independent cohort, we externally validated the predictive performance of the mPAGE\u2010B score and compared it with those of conventional HCC prediction models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We consecutively recruited CHB patients treated with lamivudine, entecavir or tenofovir as the first\u2010line antiviral regimen. Patients with decompensated cirrhosis or HCC at baseline were excluded. Predictive performances of the mPAGE\u2010B score and other models were assessed with comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1330 patients, 9.6% developed HCC during follow\u2010up. The mPAGE\u2010B score provided the highest Harrell's c\u2010index (0.769), followed by the GAG\u2010HCC (0.751), PAGE (0.744), REACH\u2010B (0.686) and CU\u2010HCC (0.618) scores. The mPAGE\u2010B score showed the similar performance to the PAGE\u2010B and GAG\u2010HCC scores and the better performance than the REACH\u2010B and CU\u2010HCC scores. Cumulative HCC probabilities at 5\u2010 and 7\u2010years were 0.0% and 0.0% in low\u2010risk group (mPAGE\u2010B score\u00a0\u2264\u00a08), 6.1% and 10.8% in intermediate\u2010risk group (mPAGE\u2010B score 9\u201012) and 18.7% and 26.7% in high\u2010risk group (mPAGE\u2010B score\u00a0\u2265\u00a013) respectively (both\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 between adjacent two groups). C\u2010indices of the mPAGE\u2010B score were 0.785 and 0.724 among subgroups treated with entecavir or tenofovir (n\u00a0=\u00a01011) and with lamivudine (n\u00a0=\u00a0319), respectively, which are overall similar to those of the PAGE\u2010B score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The mPAGE\u2010B score showed acceptable predictive performances. Compared to the PAGE\u2010B score, addition of albumin as a constituent provided the marginal benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.14129","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T07:59:54Z","timestamp":1556870394000},"page":"1624-1630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["External validation of the modified PAGE\u2010B score in Asian chronic hepatitis B patients receiving antiviral therapy"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-3560","authenticated-orcid":false,"given":"Hye Won","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal medicine Yonsei University College of medicine Seoul Republic of Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-8050","authenticated-orcid":false,"given":"Seung Up","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal medicine Yonsei University College of medicine Seoul Republic of Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-2224","authenticated-orcid":false,"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal medicine Yonsei University College of medicine Seoul Republic of Korea"},{"name":"Yonsei Liver Center Severance Hospital Seoul Republic of Korea"},{"name":"Institute of Gastroenterology Yonsei University College of medicine Seoul Republic of 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