{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:10:56Z","timestamp":1784693456108,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Nonalcoholic fatty liver disease (NAFLD) is known to increase the risk of adenomatous colonic polyps. However, the role of screening colonoscopy in patients with biopsy\u2010proven NAFLD in detecting advanced colorectal neoplasm is not clearly evidence\u2010based. Therefore, we investigated whether the histological severity of NAFLD is associated with advanced colorectal neoplasm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included patients \u226518\u00a0years old who underwent screening colonoscopy between 2013 and 2018 within a biopsy\u2010evaluated prospective NAFLD cohort. Advanced colorectal neoplasm was defined as an adenomatous polyp greater than 10\u00a0mm in diameter and\/or with villous histology and\/or with high\u2010grade dysplasia or adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 476 patients with clinically suspected NAFLD, 379 patients\u00a0were diagnosed with biopsy\u2010proven NAFLD and 97 patients had no evidence of NAFLD histologically, who were analyzed as healthy controls. The prevalence of advanced colorectal neoplasm was 11.1% (n\u00a0=\u00a053). Patients with advanced colorectal neoplasm had higher grade of steatosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) and higher stage of hepatic fibrosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.044) than those with normal colonoscopic findings or low\u2010grade adenomatous polyp. Multivariable logistic regression analysis revealed that the presence of nonalcoholic steatohepatitis (NASH) was an independent risk factor for both colorectal polyp (odds ratio [OR], 2.08; 95% confidential interval [CI], 1.12\u20103.86; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.020) and advanced colorectal neoplasm (OR, 2.81; 95% CI, 1.01\u20107.87; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.049).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of biopsy\u2010proven NASH was significantly associated with an increased risk of advanced colorectal neoplasm among patients with NAFLD. This finding may alert physicians to conduct screening colonoscopy in patients with NASH to detect advanced colorectal neoplasm early.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14163","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T12:01:27Z","timestamp":1559649687000},"page":"1722-1731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Nonalcoholic steatohepatitis is associated with a higher risk of advanced colorectal neoplasm"],"prefix":"10.1111","volume":"39","author":[{"given":"Yuri","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Internal Medicine CHA Gangnam Medical Center, CHA University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Kyung","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae Kyung","family":"Joo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Hyong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University College of Medicine, Seoul National 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