{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:58:50Z","timestamp":1788055130873,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aim<\/jats:title><jats:p>Chronic infections with hepatitis B or C (HBV and HCV) are associated with adverse clinical outcomes and patient\u2010reported outcomes (PROs). The aim is to compare PRO scores in patients with chronic HBV and HCV without advanced liver disease before and after suppression\/clearance of their infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with HCV and HBV infection prior to initiation of antiviral treatment and after viral suppression\/eradication completed PRO questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 132 patients with HBV and 132 matched patients with HCV. Baseline PRO scores were significantly higher in patients with HBV in the domains of Physical Functioning, Role Physical, Bodily Pain, Social Functioning, and Role Emotional of SF\u201036, SF\u20106D utility, Emotional and Fatigue domains of CLDQ, Presenteeism and total Work Productivity Impairment of WPAI:SHP in comparison to patients with HCV by 5.8%\u201013.2% of a PRO score range (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). After viral suppression (HBV DNA\u00a0&lt;\u00a020\u00a0IU\/mL after 48\u00a0weeks of treatment for HBV) or eradication (SVR\u201012 for HCV), only Physical Functioning and Role Physical scores remained higher in HBV by 6.7%\u20109.9%, while other PRO scores became similar between HBV and HCV groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). The most prominent improvement of PROs in HCV was noted in Vitality, Emotional, Fatigue and Worry domains. In addition, General Health, Worry and Work Productivity scores were the most improved in HBV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prior to treatment, PRO scores were lower in patients with HCV in comparison to HBV. After successful treatment, both groups of patients experienced improvement in some PRO domains confirming the positive impact of treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14171","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T14:15:10Z","timestamp":1559916910000},"page":"1837-1844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Patient\u2010reported outcomes in patients chronic viral hepatitis without cirrhosis: The impact of hepatitis B and C viral replication"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-577X","authenticated-orcid":false,"given":"Zobair M.","family":"Younossi","sequence":"first","affiliation":[{"name":"Center for Liver Diseases, Department of Medicine Inova Fairfax Hospital Falls Church Virginia"},{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stepanova","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research in Liver Disease Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issah","family":"Younossi","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research in Liver Disease Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3518-4060","authenticated-orcid":false,"given":"George","family":"Papatheodoridis","sequence":"additional","affiliation":[{"name":"Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry L.A.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Toronto Centre for Liver Disease University Health Network Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-4989","authenticated-orcid":false,"given":"Mindie H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Gane","sequence":"additional","affiliation":[{"name":"Auckland Clinical Studies Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoky","family":"Tsai","sequence":"additional","affiliation":[{"name":"Queens Medical Center University of Hawaii Honolulu Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema","family":"Nader","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research in Liver Disease Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"SarinSK MaiwallR.Global burden of liver disease: a true burden on health sciences and economies.http:\/\/www.worldgastroenterology.org\/publications\/e-wgn\/e-wgn-expert-point-of-view-articles-collection\/global-burden-of-liver-disease-a-true-burden-on-health-sciences-and-economies. 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