{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:19:39Z","timestamp":1778570379535,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>In cirrhosis, hepatic venous pressure gradient (HVPG) and imaging body composition assessment can influence prognosis. We assessed whether adipose and skeletal muscle tissues reflect the severity of portal hypertension (PH), and whether they improve non\u2010invasive prediction of decompensation and death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 84 cirrhosis patients with HVPG and computed tomography (CT) within 12\u00a0weeks of HVPG at a single centre. L3 vertebra CT images were used for body composition indexes (cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>): total adipose tissue index (TATI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), intramuscular adipose tissue index (IMATI), skeletal muscle index (SMI) and psoas muscle index (PMI). Correlations were calculated between indexes, HVPG and standard non\u2010invasive tests for PH. Twelve\u2010month decompensation and death predictors were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The following were the characteristics for the patients included in the study: male 61%; BMI 28\u00a0\u00b1\u00a05\u00a0kg\/m<jats:sup>2<\/jats:sup>; alcoholic liver disease in 51%, non\u2010alcoholic steatohepatitis in 24%; HVPG 14\u00a0\u00b1\u00a06\u00a0mm\u00a0Hg; 45% compensated. The median follow\u2010up was 11 (4\u201017) months. HVPG correlated with SATI (<jats:italic>r\u00a0<\/jats:italic>=\u00a0\u22120.282, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), TATI (<jats:italic>r\u00a0<\/jats:italic>=\u00a0\u22120.220, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.045) and SATI\/VATI index (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.240, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). In compensated patients, lower VATI (HR 0.94 (0.90\u20100.99), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) was associated with 12\u2010month decompensation. Combining TATI and liver stiffness\u00a0\u00d7\u00a0spleen size over\u2010platelet count risk score added discriminative capacity for 12\u2010month decompensation (AUROC 0.91 vs 0.87). IMATI was independently associated with mortality in decompensated patients. MELD\u2010Na combined with IMATI discriminated excellently for mortality (AUROC 0.94; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hepatic venous pressure gradient inversely correlates with imaging markers of adipose tissue, while markers of sarcopenia were unrelated to PH. In compensated patients, TATI improves non\u2010invasive prediction of decompensation. In decompensated patients, IMATI independently predicted mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14175","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T16:22:27Z","timestamp":1560788547000},"page":"1672-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Adipopenia correlates with higher portal pressure in patients with cirrhosis"],"prefix":"10.1111","volume":"39","author":[{"given":"Susana G.","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Department of Biomedical Research, Swiss Liver Center, UVCM, Inselspital, Bern University Hospital University of Bern Bern Switzerland"},{"name":"Faculty of Medicine University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Brabandt","sequence":"additional","affiliation":[{"name":"Radiology, Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Stirnimann","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Swiss Liver Center, UVCM, Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin H.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Radiology, Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4562-9016","authenticated-orcid":false,"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Swiss Liver Center, UVCM, Inselspital, Bern University Hospital University of Bern Bern 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