{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:08Z","timestamp":1787015828337,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Curing hepatitis C virus (HCV) infection reduces the risk of hepatocellular carcinoma (HCC) development, yet HCC occurs despite sustained virologic response (SVR) in 2%\u20108% of cirrhotic patients. Sphingolipids (SLs) have been identified as new biomarkers of chronic liver disease and HCC. The aim of this study was to evaluate serum SLs as diagnostic HCC biomarkers in patients with HCV\u2010associated cirrhosis at SVR12.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2014 to 2016, 166 patients with HCV\u2010cirrhosis and SVR were recruited and SL profiles were measured at baseline and 12\u00a0weeks after completion of direct\u2010acting antiviral (DAA) therapy. All patients received HCC surveillance in line with current guideline recommendations. Minimum follow\u2010up period comprised 6\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our study included 130 (78%) patients without history of HCC, 25 (15%) with history of HCC prior DAA therapy and 11 (7%) patients with de novo HCC after FU12. In those with upcoming de novo HCC serum C24DHC (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.006), C24:1DHC (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.048) and C16Cer (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.011) were significantly upregulated at FU12, but not AFP (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.138). Contemporaneous ultrasound did not visualize HCC, at this time. C16Cer stayed sole independent predictor with high diagnostic accuracy of AFP\u2010positive (AUC\u00a0=\u00a00.741) and \u2010negative (AUC\u00a0=\u00a00.766) HCC development. Serum SL parameters decreased from baseline to SVR12.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>C24DHC, C24:1DHC and especially C16Cer were superior to AFP in early detection of AFP\u2010positive and \u2010negative de novo HCC development. We observed significant SL profile changes upon SVR. SLs may play a role in non\u2010invasive HCC surveillance and hepatocarcinogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.14178","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T12:34:50Z","timestamp":1560774890000},"page":"2174-2183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Serum sphingolipids predict de novo hepatocellular carcinoma in hepatitis C cirrhotic patients with sustained virologic response"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-7246","authenticated-orcid":false,"given":"Victoria T.","family":"M\u00fccke","sequence":"first","affiliation":[{"name":"Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Thomas","sequence":"additional","affiliation":[{"name":"Pharmazentrum Frankfurt, Institut 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Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Pfeilschifter","sequence":"additional","affiliation":[{"name":"Pharmazentrum Frankfurt, Institut f\u00fcr Allgemeine Pharmakologie und Toxikologie Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Vermehren","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-9910","authenticated-orcid":false,"given":"Fabian","family":"Finkelmeier","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Grammatikos","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"},{"name":"St. Luke\u2019s 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