{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:00:49Z","timestamp":1780999249888,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>The potential interaction between family history of liver cancer and HBV infection on liver cancer has not been fully examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a population\u2010based case\u2010control study composed of 2011 liver cancer cases and 7933 controls in Jiangsu province, China from 2003 to 2010. Data on major risk or protective factors were\u00a0collected and HBV\/HCV sero\u2010markers were assayed using blood samples. Semi\u2010Bayes (SB) adjustments were applied to provide posterior estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both family history of liver cancer (adjusted odds ratios [OR]: 4.32, 95% confidence intervals [CI]: 3.25\u20105.73) and hepatitis B surface antigen (HBsAg) positivity (adjusted OR: 9.94, 95% CI: 8.33\u201011.87) were strongly associated with liver cancer development. For individuals with different combinations of serological markers, the adjusted ORs were 8.45 (95% CI: 5.16\u201013.82) for HBsAg\u2010 and HBcAb\u2010positive; 7.57 (95% CI: 4.87\u201011.77) for HBsAg\u2010, HBeAg\u2010 and HBcAb\u2010positive; and 3.62 (95% CI: 2.47\u20105.31) for HBsAg\u2010, HBeAb\u2010 and HBcAb\u2010positive, compared to all negatives in HBV serological markers. One log increase in HBV DNA level was associated with 17% increased risk (adjusted OR: 1.17, 95% CI: 1.03\u20101.32). The SB\u2010adjusted OR of HBV\u2010positive individuals with family history of liver cancer was 41.34 (95% posterior interval [PI]: 23.69\u201072.12) compared with those HBV\u2010negative without family history. Relative excess risk due to additive interaction, the attributable proportion and synergy index were 73.13, 0.87 and 8.04 respectively. Adjusted ratio of OR for multiplicative interaction was 2.84 (95% CI: 1.41\u20105.75).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Super\u2010additive and super\u2010multiplicative interactions may exist between family history of liver cancer and HBV infection on the development of liver cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14182","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T22:59:31Z","timestamp":1561244371000},"page":"1490-1503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Family history of liver cancer may modify the association between HBV infection and liver cancer in a Chinese population"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1385-9749","authenticated-orcid":false,"given":"Xing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Fielding 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