{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:55:10Z","timestamp":1759010110264,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1142976","1112297"],"award-info":[{"award-number":["1142976","1112297"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite highly effective direct\u2010acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection, some patients experience virological relapse. Salvage regimens should include multiple agents to suppress emergence of resistance\u2010associated substitutions (RAS) and minimise treatment failure. The combination of sofosbuvir (SOF) and elbasvir\/grazoprevir (ELB\/GZR) \u00b1ribavirin (RBV) is an effective retreatment strategy for HCV genotype (GT)1 and 4 infection. We hypothesised that SOF and ELB\/GZR (\u00b1RBV) would also be an effective salvage regimen for DAA\u2010experienced GT3 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the efficacy and safety of SOF\/ELB\/GZR\u00a0\u00b1\u00a0RBV in DAA\u2010experienced participants with chronic HCV infection who had prior relapse. Participants were treated at four hospitals between December 2016 and March 2018 for either 12\u2010 or 16\u2010weeks. The primary endpoint was sustained virological response at week 12 post\u2010treatment (SVR12) using intention\u2010to\u2010treat analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 40 participants included in the analysis. The mean age was 53\u00a0years, 53% had GT3, 33% had GT1 infection and 63% had cirrhosis. Fifty\u2010eight percent were treated for 12\u00a0weeks, 42% were treated for 16\u00a0weeks and 90% received RBV. The SVR12 rate was 98% overall, 100% in non\u2010GT3 participants and 95% in GT3 participants. One GT3 cirrhotic participant relapsed. ELB\/GZR was stopped at week 6 in one GT3 cirrhotic participant who switched to SOF\/velpatasvir\/RBV for a further 12\u00a0weeks and achieved SVR12. RBV dose reduction was required in two participants. Treatment was otherwise well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The combination of SOF\/ELB\/GZR\u00a0\u00b1\u00a0RBV is effective and safe for difficult\u2010to\u2010cure patients who relapse after first\u2010line DAA, including those with cirrhosis and GT3 infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14201","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T15:28:40Z","timestamp":1564414120000},"page":"2285-2290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Retreatment with elbasvir, grazoprevir, sofosbuvir\u00a0\u00b1\u00a0ribavirin is effective for GT3 and GT1\/4\/6 HCV infection after relapse"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0296-8624","authenticated-orcid":false,"given":"Timothy","family":"Papaluca","sequence":"first","affiliation":[{"name":"St Vincent\u2019s Hospital and the University of Melbourne Fitzroy Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Sinclair","sequence":"additional","affiliation":[{"name":"The Austin Hospital Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Gow","sequence":"additional","affiliation":[{"name":"The Austin Hospital Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Pianko","sequence":"additional","affiliation":[{"name":"Monash Health and Monash University Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Sievert","sequence":"additional","affiliation":[{"name":"Monash Health and Monash University Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niranjan","family":"Arachchi","sequence":"additional","affiliation":[{"name":"Western Health Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla","family":"Cameron","sequence":"additional","affiliation":[{"name":"Western Health Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Bowden","sequence":"additional","affiliation":[{"name":"Victorian Infectious Disease Reference Laboratory Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacinta","family":"O\u2019Keefe","sequence":"additional","affiliation":[{"name":"Victorian Infectious Disease Reference Laboratory Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Alfred and Monash University Melbourne Vic. Australia"},{"name":"Burnet Institute Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Stoove","sequence":"additional","affiliation":[{"name":"Burnet Institute Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Hellard","sequence":"additional","affiliation":[{"name":"Burnet Institute Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Iser","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Hospital and the University of Melbourne Fitzroy Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Thompson","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Hospital and the University of Melbourne Fitzroy Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3181"},{"key":"e_1_2_9_4_1","unstructured":"Therapeutic goods administration. Product Information Zepatier.https:\/\/www.tga.gov.au\/sites\/default\/files\/auspar-grazoprevir-170515-pi.pdf. Accessed September 15 2018."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix916"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12719"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29852"},{"key":"e_1_2_9_8_1","unstructured":"Pharmaceutical Benefit Scheme; Australian Government.'General Statement for Drugs for the Treatment of Hepatitis C'.http:\/\/www.pbs.gov.au\/healthpro\/explanatory-notes\/general-statement-pdf\/general-statement-hepatitis-cpdf. Accessed December 6 2018."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i35.8050"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613512"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"102A","article-title":"Sofosbuvir\/velpatasvir\/voxilaprevir for 12 weeks as a salvage regimen in NS5A inhibitor\u2010experienced patients with genotype 1\u20136 infection: the phase 3 POLARIS\u20101 study","volume":"64","author":"Bourli\u00e8re M","year":"2016","journal-title":"Hepatology"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29256"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00763-16"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.025"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.14201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.14201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T15:49:31Z","timestamp":1694188171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.14201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/liv.14201"],"URL":"https:\/\/doi.org\/10.1111\/liv.14201","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"type":"print","value":"1478-3223"},{"type":"electronic","value":"1478-3231"}],"subject":[],"published":{"date-parts":[[2019,8,13]]},"assertion":[{"value":"2019-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}