{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:36:58Z","timestamp":1778672218139,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TRR57 P18"],"award-info":[{"award-number":["SFB TRR57 P18"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008050","name":"Fundaci\u00f3n Cellex","doi-asserted-by":"publisher","award":["825694"],"award-info":[{"award-number":["825694"]}],"id":[{"id":"10.13039\/100008050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Renal function assessed by creatinine is a key prognostic factor in cirrhotic patients. However, creatinine is influenced by several factors, rendering interpretation difficult in some situations. This is especially important in early stages of renal dysfunction where renal impairment might not be accompanied by an increase in creatinine. Other parameters, such as cystatin C (CysC) and beta\u2010trace protein (BTP), have been evaluated to fill this gap. However, none of these studies have considered the role of the patient's sex. The present study analysed CysC and BTP to evaluate their prognostic value and differentiate them according to sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>CysC and BTP were measured in 173 transjugular intrahepatic portosystemic shunt (TIPS)\u2010patients from the NEPTUN\u2010STUDY(NCT03628807) and analysed their relationship with mortality and sex. Propensity score for age, MELD, etiology and TIPS indication was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cystatin C and BTP showed excellent correlations with creatinine values at baseline and follow\u2010up. CysC was an independent predictor of overall mortality (HR\u00a0=\u00a01.66(1.33\u20102.06)) with an AUC of 0.75 and identified a cut\u2010off of 1.55\u00a0mg\/L in the whole cohort. Interestingly, CysC was significantly lower in females, also after propensity score matching. In males, the only independent predictor was the creatinine level (HR\u00a0=\u00a01.54(1.25\u20101.58)), while in females CysC levels independently predicted mortality (HR\u00a0=\u00a03.17(1.34\u20107.52)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates for the first time that in TIPS\u2010patients creatinine predicts mortality in males better than in females, whereas CysC is a better predictor of mortality in females. These results may influence future clinical decisions on therapeutic options for example, allocation for liver transplantation in TIPS\u2010patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14230","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T05:54:13Z","timestamp":1566798853000},"page":"186-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sex specificity of kidney markers to assess prognosis in cirrhotic patients with TIPS"],"prefix":"10.1111","volume":"40","author":[{"given":"Maria","family":"Torner","sequence":"first","affiliation":[{"name":"European Foundation for the Study of Chronic Liver Failure Barcelona Spain"},{"name":"Department of Gastroenterology Hospital Universitario Central de Asturias Oviedo Spain"},{"name":"Liver ICU, Liver Unit Hospital Clinic y Provencial de Barcelona Barcelona 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