{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:31:50Z","timestamp":1781796710194,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572808"],"award-info":[{"award-number":["81572808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773252"],"award-info":[{"award-number":["81773252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7162190"],"award-info":[{"award-number":["7162190"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease manifested with the aberrant activation of hepatic dendritic cells (HDCs) and the subsequent breakdown of immune homeostasis. As an important player, HDC maintains immunological balance between tolerance to self\u2010antigens versus destruction against pathogens in liver. However, the intracellular signalling networks that program HDC remain unclear. We have now found the role of canonical Wnt\/\u03b2\u2010catenin signalling in HDCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Liver sections from AIH patients and healthy subjects were stained for the markers of Wnt\/\u03b2\u2010catenin signalling. Concanavalin A (ConA) and HDC\/Hepa1\u20106 vaccine\u2010induced AIH mouse models were examined for liver injury, inflammation and immune cell functions by serum biochemistry, histology, quantitative reverse transcription polymerase chain reaction (qRT\u2010PCR), enzyme\u2010linked immunosorbent assay (ELISA) and flow cytometry analysis. Wnt\/\u03b2\u2010catenin signalling expression was measured using immunoblot and qRT\u2010PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Canonical Wnt\/\u03b2\u2010catenin signalling in HDC is deficient in AIH patients and a mouse model, which coincides with the immunogenic function of HDCs. Furthermore, Wnt ligand engagement reactivates Wnt\/\u03b2\u2010catenin signalling and recovers the immunoregulatory phenotype of HDCs, in turn alleviating the severity of AIH. Likewise, pharmacologic activation of Wnt\/\u03b2\u2010catenin signalling attenuates AIH progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report here that the constitutively active canonical Wnt\/\u03b2\u2010catenin signalling confers HDCs tolerogenicity under steady\u2010state conditions. Deficiency of this pathway gives rise to T cell\u2010mediated immune response and incidence of AIH. It may act as a new pathogenesis and treatment target for AIH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14246","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T17:25:11Z","timestamp":1568136311000},"page":"131-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Deficiency of canonical Wnt\/\u03b2\u2010catenin signalling in hepatic dendritic cells triggers autoimmune hepatitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Kangan","family":"Tan","sequence":"first","affiliation":[{"name":"Infectious Diseases Department Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehai","family":"Xie","sequence":"additional","affiliation":[{"name":"General Surgery Department Peking University First Hospital Beijing 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University Youan Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8069-9901","authenticated-orcid":false,"given":"Hong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4771-0478","authenticated-orcid":false,"given":"Fengqin","family":"Hou","sequence":"additional","affiliation":[{"name":"Infectious Diseases 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