{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:59:11Z","timestamp":1790477951597,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>The loss\u2010of\u2010function <jats:italic>rs72613567 T\u00a0&gt;\u00a0TA<\/jats:italic>\u2010variant in the <jats:italic>17\u03b2\u2010hydroxysteroid dehydrogenase 13<\/jats:italic> (<jats:italic>HSD17B13<\/jats:italic>) gene might protect from alcoholic and non\u2010alcoholic fatty liver disease (ALD\/NAFLD) and associated fibrosis\/cirrhosis. We investigated the impact of the <jats:italic>T\u00a0&gt;\u00a0TA<\/jats:italic>\u2010variant on hepatic decompensation and mortality and investigated its implications on retinol and sex steroid metabolism in patients who had already developed advanced chronic liver disease (ACLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis in prospectively characterized patients with viral hepatitis\u2010 and ALD\/NAFLD\u2010induced portal hypertension (hepatic venous pressure gradient (HVPG)\u00a0\u2265\u00a06\u00a0mmHg) diagnosed at the Medical University of Vienna.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 487 patients who were followed longitudinally, 166 (34%) were heterozygous and 24 (5%) were homozygous for the \u2018protective\u2019 <jats:italic>TA<\/jats:italic>\u2010allele. Patients harbouring at least one <jats:italic>TA<\/jats:italic>\u2010allele had a lower MELD (9 (8\u201012) vs 10 (8\u201013) points; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003) and showed a trend towards lower HVPG (16\u00a0\u00b1\u00a06 vs 17\u00a0\u00b1\u00a07\u00a0mmHg; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.067). Interestingly, in competing risk analyses adjusted for age, HVPG and MELD, harbouring the <jats:italic>TA<\/jats:italic>\u2010allele was associated with numerically increased risks for mortality (adjusted subdistribution hazard ratio (aSHR): 1.3 (95% confidence interval (95% CI): 0.888\u20101.91); <jats:italic>P<\/jats:italic>\u00a0=\u00a0.18), liver\u2010related death (aSHR: 1.34 (95% CI: 0.9\u20101.98); <jats:italic>P<\/jats:italic>\u00a0=\u00a0.15) and hepatic decompensation (aSHR: 1.29 (95% CI: 0.945\u20101.77); <jats:italic>P<\/jats:italic>\u00a0=\u00a0.11). This might be explained by trends towards worse outcomes (eg liver\u2010related death: aSHR: 1.64 (95% CI: 0.95\u20102.84); <jats:italic>P<\/jats:italic>\u00a0=\u00a0.076) in patients with viral hepatitis\u2010induced ACLD. In a cross\u2010sectional analysis of 211 additional patients, serum retinol levels were comparable between <jats:italic>HSD17B13<\/jats:italic> genotypes, but in males, serum testosterone levels numerically decreased with an increasing number of <jats:italic>TA<\/jats:italic>\u2010alleles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with viral hepatitis\u2010 and ALD\u2010induced portal hypertension, the <jats:italic>T\u00a0&gt;\u00a0TA<\/jats:italic>\u2010variant was not protective of hepatic decompensation and mortality. Further studies should investigate the pathophysiological mechanisms underlying the effects of <jats:italic>HSD17B13<\/jats:italic> genotype at different stages of liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14304","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T11:25:32Z","timestamp":1575372332000},"page":"393-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impact of <i>HSD17B13 rs72613567<\/i> genotype on hepatic decompensation and mortality in patients with portal hypertension"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4904-5133","authenticated-orcid":false,"given":"Bernhard","family":"Scheiner","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab Medical 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