{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:51:39Z","timestamp":1790268699735,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,22]],"date-time":"2020-03-22T00:00:00Z","timestamp":1584835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Hepatitis C virus (HCV) genotype (GT) 4 infection is prevalent in sub\u2010Saharan Africa and the Middle East, particularly in Egypt. This study evaluated the safety and efficacy of elbasvir\/grazoprevir administered for 8 and 12\u00a0weeks in participants with HCV\u00a0GT4 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this partially randomized, open\u2010label multicentre study conducted in France (NCT03111108; Protocol MK5172\u2010096), treatment\u2010naive participants with GT4 infection and F0\u2010F2 fibrosis were randomized 2:1 to elbasvir (50\u00a0mg)\/grazoprevir (100\u00a0mg) for 8 or 12\u00a0weeks. Treatment\u2010naive participants with F3\u2010F4 fibrosis and all treatment\u2010experienced participants (F0\u2010F4) were assigned to elbasvir\/grazoprevir for 12\u00a0weeks. The primary endpoint was sustained virologic response (SVR) 12\u00a0weeks after the end of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and seventeen participants were enrolled. Among treatment\u2010naive participants with F0\u2010F2 fibrosis, SVR was achieved by 94% (50\/53) and 96% (26\/27) of those receiving elbasvir\/grazoprevir for 8 or 12\u00a0weeks, respectively, and four participants relapsed. In the 12\u2010week arm, 95% (35\/37) achieved SVR and two participants relapsed. NS5A resistance\u2010associated substitutions were present at baseline and virologic failure in five of the participants with relapse. Drug\u2010related adverse events occurred in 42% (n\u00a0=\u00a022) and 50% (n\u00a0=\u00a032) of participants receiving 8 and 12\u00a0weeks of treatment, respectively. No participant discontinued treatment owing to an adverse event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data confirm the efficacy of elbasvir\/grazoprevir administered for\u00a012\u00a0weeks in treatment\u2010experienced individuals with HCV GT4 infection and those with advanced fibrosis. Treatment\u2010naive individuals with mild fibrosis can be treated effectively with an 8\u2010week regimen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14313","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T14:56:28Z","timestamp":1574693788000},"page":"1042-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and safety of elbasvir\/grazoprevir for 8 or 12 weeks for hepatitis C virus genotype 4 infection: A randomized study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-0595","authenticated-orcid":false,"given":"Tarik","family":"Asselah","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology University Paris Diderot, Sorbonne Paris Cit\u00e9, CRI, UMR 1149 INSERM Paris France"},{"name":"Department of Hepatology AP\u2010HP H\u00f4pital Beaujon Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-9591","authenticated-orcid":false,"given":"Stanislas","family":"Pol","sequence":"additional","affiliation":[{"name":"Department of Hepatology APHP H\u00f4pital Cochin\/Universit\u00e9 Paris Descartes\/INSERM U1223 Institut Pasteur Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Hezode","sequence":"additional","affiliation":[{"name":"Department of Hepatology Henri Mondor Hospital APHP, University of Paris\u2010Est, INSERM U955 Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Loustaud\u2010Ratti","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology CHU de Limoges U850 INSERM Universit\u00e9 Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Leroy","sequence":"additional","affiliation":[{"name":"CHU de Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Nafa Si","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology P\u020fle de Recherche Clinique H\u00f4pital Saint Joseph Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violaine","family":"Ozenne","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology H\u00f4pital Saint Antoine Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Bronowicki","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology CHU de Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Larrey","sequence":"additional","affiliation":[{"name":"Department of Hepatology H\u00f4pital Saint Eloi Ecole de M\u00e9decine de Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Universit\u00e9 C\u00f4te d'Azur Nice France"},{"name":"Centre Digestif CHU de Nice Nice France"},{"name":"INSERM, U1065, C3M, Team 8 Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Alric","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Gastroenterology CHU de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8672-4146","authenticated-orcid":false,"given":"Eric","family":"Nguyen\u2010Khac","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology CHU de Amiens Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Merck &amp; Co., Inc. 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Zepatier Elbasvir\/Grazoprevir.2016.https:\/\/www.ema.europa.eu\/en\/documents\/overview\/zepatier\u2010epar\u2010summary\u2010public_en.pdf. 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