{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:57:13Z","timestamp":1791287833253,"version":"4.3.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01\u2010HC65233"],"award-info":[{"award-number":["N01\u2010HC65233"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01\u2010HC65234"],"award-info":[{"award-number":["N01\u2010HC65234"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01\u2010HC65235"],"award-info":[{"award-number":["N01\u2010HC65235"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01\u2010HC65236"],"award-info":[{"award-number":["N01\u2010HC65236"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01\u2010HC65237"],"award-info":[{"award-number":["N01\u2010HC65237"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Non\u2010alcoholic fatty liver disease (NAFLD) disproportionately affects Hispanic\/Latinos and rates of NAFLD vary among Hispanics from different background groups. Genetic variants and continental ancestry contribute to NAFLD disparities among Hispanics. We evaluated two newly identified NAFLD\u2010associated single nucleotide polymorphisms of\n                      <jats:italic>HSD17B13<\/jats:italic>\n                      , rs72613567:TA and rs62305723:A in Hispanics\/Latinos.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data, genotypes of variants of interest and estimates of continental ancestry were extracted from the Hispanic Community Health Study\/Study of Latinos (HCHS\/SOL) database, which includes a cohort of 16\u00a0415 US Hispanic\/Latinos. Surrogate endpoints for NAFLD were suspected NAFLD based on unexplained aminotransferase elevation, continuous ALT levels and FIB\u20104 scores to estimate hepatic fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 9342 participants were included for analysis. The rs72613567:TA allele was found in 15.3% and the rs62305723:A allele was identified in 4.5% of HCHS\/SOL participants. rs72613567:TA was less frequent in persons with vs without suspected NAFLD (12.4% vs 15.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and rs72613567:TA was associated with lower FIB\u20104 scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01). For persons with the NAFLD\u2010associated\n                      <jats:italic>PNPLA3<\/jats:italic>\n                      rs738409:G allele, the presence of rs72613567:TA was associated with a lower rate of suspected NAFD (odds ratio\u00a0=\u00a00.76,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). rs72613567:TA was less frequent in Hispanic\/Latino background groups with higher rates of suspected NAFLD. The rs62305723:A allele was not associated with suspected NAFLD or FIB\u20104 score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The rs72613567:TA allele is associated with lower rates of suspected NAFLD and lower FIB\u20104 scores among Hispanic\/Latinos and with lower rates of suspected NAFLD in persons with the\n                      <jats:italic>PNPLA3<\/jats:italic>\n                      rs738409:G allele. The rs72613567:TA allele contributes to NAFLD disparities among Hispanic\/Latino background groups.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.14387","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T02:09:28Z","timestamp":1579658968000},"page":"889-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Association of\n                    <i>HSD17B13<\/i>\n                    rs72613567:TA with non\u2010alcoholic fatty liver disease in Hispanics\/Latinos"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2395-7839","authenticated-orcid":false,"given":"Eric","family":"Kallwitz","sequence":"first","affiliation":[{"name":"Department of Medicine Loyola University Medical Center Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bamidele O.","family":"Tayo","sequence":"additional","affiliation":[{"name":"Parkinson School of Health Sciences and Public Health Loyola University Chicago Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Kuniholm","sequence":"additional","affiliation":[{"name":"School of Public Health State University of New York Albany NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Daviglus","sequence":"additional","affiliation":[{"name":"Institute of Minority Health Research University of Illinois Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen R.","family":"Isasi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Einstein College of Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Cotler","sequence":"additional","affiliation":[{"name":"Department of Medicine Loyola University Medical Center Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011775"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20466"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws448"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20554"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.08.037"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.02.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1712191"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30996"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30799"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30623"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30350"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2010.03.015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4063"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2015.09.006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.12.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07486.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.094052.109"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P089953"}],"container-title":["Liver 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