{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:22:08Z","timestamp":1775211728483,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T00:00:00Z","timestamp":1581811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008050","name":"Fundaci\u00f3n Cellex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Acute\u2010on\u2010chronic liver failure (ACLF) is characterized by acute decompensation of cirrhosis (AD), organ failure(s) and high risk of short\u2010term mortality with bacterial infection frequently as precipitating event. Innate immune pattern recognition receptors and members of the lectin pathway of complement activation are crucial to the innate immune response to pathogens. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) of innate immune components are associated with the occurrence of bacterial infections or mortality in patients with cirrhosis hospitalized for AD or ACLF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one innate immunity SNPs with known functional implications were genotyped in 826 AD\/ACLF patients included in the CANONIC study. Associations between baseline characteristics of the patients, the occurrence of bacterial infections and survival rate at 90\u00a0days of follow\u2010up in relation to the innate immunity genetic variants were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The NOD2\u2010G908R genetic variant was associated with mortality (HR 2.25, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) independently of age and MELD Score. This association was also found in a predefined subgroup analysis in patients with bacterial infections (HR 2.78, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) along with MBL_Yx (HR 1.72, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008) and MASP2_371 (HR 1.67, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.012) genetic variants. None of the analysed SNPs were significantly associated with the occurrence of acute bacterial infections or spontaneous bacterial peritonitis in particular.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Innate immune system\u2010specific NOD2\u2010G908R, MBL_Yx and MASP2_371 genetic variants were independently associated with increased risk of short\u2010term mortality in AD\/ACLF patients with bacterial infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14392","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T22:24:11Z","timestamp":1580250251000},"page":"646-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0691-4818","authenticated-orcid":false,"given":"Jelte J.","family":"Schaapman","sequence":"first","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c0lex","family":"Amoros","sequence":"additional","affiliation":[{"name":"European Foundation for the study of Chronic Liver Failure Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan J.","family":"van der Reijden","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0842-7813","authenticated-orcid":false,"given":"Wim","family":"Laleman","sequence":"additional","affiliation":[{"name":"UZ Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Frankfurt Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0412-8437","authenticated-orcid":false,"given":"Rafael","family":"Ba\u00f1ares","sequence":"additional","affiliation":[{"name":"Gregorio Mara\u00f1\u00f3n Hospital Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv","family":"Jalan","sequence":"additional","affiliation":[{"name":"University College London Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Arroyo","sequence":"additional","affiliation":[{"name":"European Foundation for the study of Chronic Liver Failure Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Cl\u00e0ria","sequence":"additional","affiliation":[{"name":"European Foundation for the study of Chronic Liver Failure Barcelona Spain"},{"name":"Hospital Cl\u00ednic IDIBAPS and CIBERehd Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hein W.","family":"Verspaget","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minneke J.","family":"Coenraad","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The 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