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Although high VWF\/FVIII may be risk factors for portal vein thrombosis (PVT) in patients with advanced chronic liver disease (ACLD), the impact of BT on PVT is unknown. We aimed to assess (I) whether non\u2010O\u2010BT is a risk factor for PVT and (II) whether non\u2010O\u2010BT impacts VWF\/factor VIII in patients with ACLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis comprising two cohorts: (I) \u201c<jats:italic>US<\/jats:italic>\u201d including all adult liver transplantations in the US in the MELD era and (II) \u201c<jats:italic>Vienna<\/jats:italic>\u201d comprising patients with a hepatic venous pressure gradient (HVPG) \u22656\u00a0mmHg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(I) The \u201c<jats:italic>US cohort<\/jats:italic>\u201d included 84\u00a0947 patients (non\u2010O: 55.43%). The prevalence of PVT at the time of listing (4.37% vs 4.56%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.1762) and at liver transplantation (9.56% vs 9.33%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.2546) was similar in patients with O\u2010 and non\u2010O\u2010BT. (II) 411 patients were included in the \u201cVienna cohort\u201d (non\u2010O: 64%). Mean HVPG was 18(9) mmHg and 90% had an HVPG \u226510\u00a0mmHg. Patients with non\u2010O\u2010BT had slightly increased VWF levels (318(164)% vs 309(176)%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.048; increase of 23.8%\u201023.9% in adjusted analyses), but this difference was driven by patients with less advanced disease. However, non\u2010O\u2010BT explained only 1% of the variation in VWF and had no effect on FVIII.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although non\u2010O\u2010BT impacts VWF in patients with early stage ACLD, its contribution to VWF variation is considerably smaller than in the general population. Moreover, non\u2010O\u2010BT had no impact on FVIII. These findings may explain the absence of an association between non\u2010O\u2010BT and PVT in patients with advanced cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14404","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T09:10:37Z","timestamp":1581585037000},"page":"1415-1426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The impact of ABO blood type on the prevalence of portal vein thrombosis in patients with advanced chronic liver disease"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4904-5133","authenticated-orcid":false,"given":"Bernhard","family":"Scheiner","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Laboratory Medical University of Vienna Vienna 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