{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T18:58:30Z","timestamp":1775761110865,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270533"],"award-info":[{"award-number":["81270533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470038"],"award-info":[{"award-number":["81470038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Current guidelines on the management of bacterascites are limited. This multicentre, retrospective study investigated the clinical features and outcomes of cirrhosis patients with bacterascites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two series of cirrhosis patients were evaluated. The first included 418 patients with ascites\u2010positive cultures at 11 hospitals during 2012\u20102018. Clinical characteristics and outcomes were recorded. The second included 208 patients with sterile ascites from a prospective cohort (NCT02457637). Clinical features and outcomes of cirrhotic patients with or without bacterascites were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first series, bacterascites was diagnosed in 254\/418 (60.8%) patients, and culture\u2010positive spontaneous bacterial peritonitis (SBP) in 164\/418 (39.2%) patients. Gram\u2010positive bacteria were more prevalent in bacterascites patients than in culture\u2010positive SBP patients (59.1% vs 22.0%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). For patients with acute\u2010on\u2010chronic liver failure (ACLF) in bacterascites and culture\u2010positive SBP groups, the 28\u2010day transplant\u2010free mortality (41.3% vs 65.5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015) and the prevalence of in\u2010hospital acute kidney injury (AKI) (84.8% vs 75%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.224). For patients without ACLF in the bacterascites (n\u00a0=\u00a0208) and culture\u2010positive SBP groups (n\u00a0=\u00a0108), the 28\u2010day transplant\u2010free mortalities were 13% vs 13.9% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.822), the probabilities of progression to ACLF within 28\u00a0days were 10.1% vs 14.8% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.216) and the prevalences of in\u2010hospital AKI were 14.4% vs 30.6% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Bacterascites patients had higher 28\u2010day mortality than those patients with sterile ascites, after propensity score matching (18.4% vs 8.6%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bacterascites patients had non\u2010negligible poor clinical outcomes, including in\u2010hospital AKI, progression to ACLF and 28\u2010day mortality. Future studies are warranted to expedite the diagnosis of bacterascites and optimize antibiotic treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14418","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T07:36:25Z","timestamp":1583307385000},"page":"1447-1456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical features and outcomes of bacterascites in cirrhotic patients: A retrospective, multicentre study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-5632","authenticated-orcid":false,"given":"Beiling","family":"Li","sequence":"first","affiliation":[{"name":"Hepatology Unit Department of Infectious Diseases Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hepatology The First Hospital of Jilin University (JU) Jilin China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Integrative Medicine Beijing Ditan Hospital Capital Medical University Beijing China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiping","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Liver Intensive Care Unit Shanghai Public Health Clinical Centre (SPHCC) Fudan University Shanghai China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongji","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Taihe Hospital Hubei University of Medicine Hubei China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hunan Key Laboratory of Viral Hepatitis Xiangya Hospital Central South University Hunan China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Southwest Hospital Third Military Medical University (Army Medical University) Chongqing China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Lu","sequence":"additional","affiliation":[{"name":"Infectious Disease Centre The First Affiliated Hospital of Xinjiang Medical University (XMU) Xinjiang China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hepatology The Second Hospital of Shandong University (SDU) Jinan China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Institute of Infection and Immunology Union Hospital Tongji Medical College Huazhong University of Science and Technology Hubei China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4275-9149","authenticated-orcid":false,"given":"Jinjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Hepatology Unit Department of Infectious Diseases Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Chinese (acute on) Chronic Liver Failure Consortium (Ch\u2010CLIF.C)  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