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Lung lesions have been considered as the major damage caused by SARS\u2010CoV\u20102 infection. However, liver injury has also been reported to occur during the course of the disease in severe cases. Similarly, previous studies have shown that liver damage was common in the patients infected by the other two highly pathogenic coronavirus \u2013 severe acute respiratory syndrome coronavirus (SARS\u2010CoV) and the Middle East respiratory syndrome coronavirus (MERS\u2010CoV), and associated with the severity of diseases. In this review, the characteristics and mechanism of liver injury caused by SARS\u2010CoV, MERS\u2010CoV as well as SARS\u2010CoV\u20102 infection were summarized, which may provide help for further studies on the liver injury of COVID\u201019.<\/jats:p>","DOI":"10.1111\/liv.14435","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T08:05:05Z","timestamp":1584173105000},"page":"998-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":672,"title":["Liver injury during highly pathogenic human coronavirus infections"],"prefix":"10.1111","volume":"40","author":[{"given":"Ling","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Joint International Laboratory of Infection and Immunity Huazhong University of Science and Technology Wuhan 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