{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:11:51Z","timestamp":1791364311625,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1382"],"award-info":[{"award-number":["CRC 1382"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TRR57"],"award-info":[{"award-number":["SFB TRR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Liver stiffness measured with 2\u2010dimensional shear wave elastography by Supersonic Imagine (2DSWE\u2010SSI) is well\u2010established for fibrosis diagnostics, but non\u2010conclusive for portal hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an individual patient data meta\u2010analysis of 2DSWE\u2010SSI to identify clinically significant portal hypertension (CSPH), severe portal hypertension and large varices in cirrhosis patients, using hepatic venous pressure gradient and upper endoscopy as reference. We used meta\u2010analytical integration of diagnostic accuracies with optimized rule\u2010out (sensitivity\u201090%) and rule\u2010in (specificity\u201090%) cut\u2010offs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five studies from seven centres shared data on 519 patients. After exclusion, we included 328 patients. Eighty\u2010nine (27%) were compensated and 286 (87%) had CSPH. 2DSWE\u2010SSI\u00a0&lt;\u00a014\u00a0kPa ruled out CSPH with a summary AUROC (sROC), sensitivity and specificity of 0.88, 91% and 37%, and correctly classified 85% of patients, with minimal between\u2010study heterogeneity. The false negative rate was 60%, of which decompensated patients accounted for 78%. 2DSWE\u2010SSI\u00a0\u2265\u00a032\u00a0kPa ruled in CSPH with sROC, sensitivity, specificity and correct classifications of 0.83, 47%, 89% and 55%. In a subgroup analysis, the 14\u00a0kPa cut\u2010off showed consistent sensitivity and higher specificity for patients with compensated cirrhosis, without ascites, viral aetiology or BMI\u00a0&lt;\u00a025\u00a0kg\/m<jats:sup>2<\/jats:sup>. 2DSWE\u2010SSI ruled out severe portal hypertension and large varices with fewer correctly classified and lower sROC, and with minimal benefit for ruling in.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver stiffness using 2\u2010dimensional shear wave elastography below 14\u00a0kPa may be used to rule out clinically significant portal hypertension in cirrhosis patients, but this would need validation in populations of compensated liver disease. 2DSWE\u2010SSI cannot predict varices needing treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14439","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T06:59:57Z","timestamp":1584428397000},"page":"1435-1446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["2D shear wave liver elastography by Aixplorer to detect portal hypertension in cirrhosis: An individual patient data meta\u2010analysis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1854-1924","authenticated-orcid":false,"given":"Maja","family":"Thiele","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology and OPEN Patient Data Explorative Network Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-3565","authenticated-orcid":false,"given":"Mie B.","family":"Hugger","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology and OPEN Patient Data Explorative Network Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology College of Medicine Hanyang University Guri Hospital Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Emmanuel","family":"Rautou","sequence":"additional","affiliation":[{"name":"Centre de recherche sur l'inflammation Inserm Universit\u00e9 de Paris Paris France"},{"name":"Service d'H\u00e9patologie DMU Digest H\u00f4pital Beaujon, AP\u2010HP 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