{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:09:55Z","timestamp":1790435395489,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Science Foundation","award":["2019J01440"],"award-info":[{"award-number":["2019J01440"]}]},{"name":"Startup Fund for Scientific Research","award":["2017XQ1080"],"award-info":[{"award-number":["2017XQ1080"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) has raised world concern for global epidemic since December, 2019. Limited data are available for liver function in COVID\u201019 patients. We aimed to investigate the risk factors related to liver injury in the COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed in non\u2010ICU Ward at Jinyintan Hospital from February 2, 2020 to February 23, 2020. Consecutively confirmed COVID\u201019 discharged cases were enrolled. The clinical characteristics of patients with liver injury and without liver injury were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 79 COVID\u201019 patients were included. 31.6%, 35.4% and 5.1% COVID\u201019 patients had elevated levels of alanine transaminase (ALT), aspartate aminotransferase (AST) and bilirubin respectively. Median value of ALT, AST and bilirubin for entire cohort was 36.5 (17.5\u00a0~\u00a071.5) U\/L, 34.5 (25.3\u00a0~\u00a055.3) U\/L and 12.7 (8.1\u00a0~\u00a015.4) mmol\/L respectively. There were no significant differences in age, previous medical history and symptoms between the two groups. Males were more likely to have liver injury when infected with COVID\u201019 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05); compared with patients without liver injury, patients with liver injury had increased levels of white blood cell counts, neutrophils, CRP and CT score (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) and had a longer length of stay (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Logistic regression analyses suggested that the extent of pulmonary lesions on CT was a predictor of liver function damage (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liver injury is common in non\u2010ICU hospitalized COVID\u201019 patients. It may be related to systemic inflammation. Intense monitoring and evaluation of liver function in patients with severe pulmonary imaging lesions should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14449","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T07:47:05Z","timestamp":1585813625000},"page":"1321-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":228,"title":["Clinical characteristics of non\u2010ICU hospitalized patients with coronavirus disease 2019 and liver injury: A retrospective study"],"prefix":"10.1111","volume":"40","author":[{"given":"Hansheng","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2638-3372","authenticated-orcid":false,"given":"Ningfang","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-9859","authenticated-orcid":false,"given":"Su","family":"Lin","sequence":"additional","affiliation":[{"name":"Liver research center The First Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunfang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichang","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25818"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa247"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14435"},{"key":"e_1_2_10_6_1","volume-title":"Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance","author":"World Health Organization"},{"key":"e_1_2_10_7_1","unstructured":"Novel coronavirus pneumonia prevention and control program(6th ed.). (in Chinese).http:\/\/www.nhc.gov.cn\/yzygj\/s7653p\/202002\/8334a8326dd94d329df351d7da8aefc2.shtml. Accessed 18 February 2020."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2363040958"},{"key":"e_1_2_10_9_1","first-page":"148","article-title":"Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study","volume":"28","author":"Liu C","year":"2020","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.03.008"},{"key":"e_1_2_10_14_1","first-page":"E002","article-title":"Exploring the mechanism of liver enzyme abnormalities in patients with novel coronavirus\u2010infected pneumonia","volume":"28","author":"Guan GW","year":"2020","journal-title":"Zhonghua Gan Zang Bing Za Zhi"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.14449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.14449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T06:58:19Z","timestamp":1694415499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.14449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,12]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/liv.14449"],"URL":"https:\/\/doi.org\/10.1111\/liv.14449","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,12]]},"assertion":[{"value":"2020-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}