{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:29:00Z","timestamp":1788478140879,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The SARS\u2010CoV\u20102 pandemic is an ongoing global health emergency. The aim of our study was to investigate the changes of liver function and its clinical significance in COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective, single\u2010centre study was conducted on 115 confirmed cases of COVID\u201019 in Zhongnan hospital of Wuhan University from 18 January 2020 to 22 February 2020. Liver function and related indexes were analysed to evaluate its relationship with disease progression in COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Part of the COVID\u201019 patients presented with varying degrees of abnormality in liver function indexes. However, the levels of ALT, AST, TBIL, GGT and LDH in COVID\u201019 patients were not significantly different when compared with hospitalised community\u2010acquired pneumonia patients, and the levels of albumin is even significantly higher. The levels of ALT, AST, TBIL, LDH and INR showed statistically significant elevation in severe COVID\u201019 cases compared with that in mild cases. However, the clinical significance of the elevation is unremarkable. Majority of severe COVID\u201019 patients showed significantly decreasing in albumin level and continuously decreasing in the progress of illness. Most of the liver function indexes in COVID\u201019 patients were correlated with CRP and NLR, the markers of inflammation. Logistic regression analysis further identified NLR as the independent risk factor for severe COVID\u201019, as well as age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although abnormalities of liver function indexes are common in COVID\u201019 patients, the impairment of liver function is not a prominent feature of COVID\u201019, and also may not have serious clinical consequences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14455","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T15:49:24Z","timestamp":1585842564000},"page":"2095-2103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":356,"title":["Liver impairment in COVID\u201019 patients: A retrospective analysis of 115 cases from a single centre in Wuhan city, China"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3329-8029","authenticated-orcid":false,"given":"Yafei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Zhongnan Hospital of Wuhan University Wuhan China"},{"name":"Clinical Center and Key Lab of Intestinal and Colorectal Diseases of Hubei Province Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Research Center for Translational Medicine Shanghai East Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongnan Hospital of Wuhan University Wuhan China"},{"name":"Clinical Center and Key Lab of Intestinal and Colorectal Diseases of Hubei Province Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongnan Hospital of Wuhan University Wuhan China"},{"name":"Clinical Center and Key Lab of Intestinal and Colorectal Diseases of Hubei Province Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhongnan Hospital of Wuhan University Wuhan China"},{"name":"Clinical Center and Key Lab of Intestinal and Colorectal Diseases of Hubei Province Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12020244"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020575"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20069"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.11.024"},{"key":"e_1_2_9_8_1","unstructured":"http:\/\/www.nhc.gov.cn\/yzygj\/s7653p\/202002\/d4b895337e19445f8d728fcaf1e3e13a\/files\/ab6bec7f93e64e7f998d802991203cd6.pdf. 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