{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:19:42Z","timestamp":1780589982942,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Special Fund of Chinese Central Government for Basic Scientific Research Operations in Commonweal Research Institutes","award":["2017PT63001"],"award-info":[{"award-number":["2017PT63001"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2016-I2M-3-001"],"award-info":[{"award-number":["2016-I2M-3-001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have examined the risk of gastrointestinal cancers in screen\u2010detected gallstone disease. This study aimed to investigate the association between screen\u2010detected gallstone disease and gastrointestinal cancers using the Kailuan cohort, a population\u2010based prospective cohort initiated in 2006.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 79\u00a0809 men who underwent gallbladder ultrasonography, were free of cancers in 2006 and did not have gastrointestinal cancers within one year were enrolled. A Cox proportional hazards model with age as the timescale was used to evaluate the association between screen\u2010detected gallstone disease and gastrointestinal cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 1264 cases with gastrointestinal cancers, including 303 cases with liver cancer and 94 cases with pancreatic cancer. Screen\u2010detected gallstone disease increased the risk of liver cancer, with an HR of 2.28 [95% confidence interval (CI): 1.20\u20104.33, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.012]. The association was modified by the hepatitis B surface antigen status. A non\u2010significant positive association was observed between pancreatic cancer and gallstone disease (HR 2.19, 95% CI: 0.95\u20105.05, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.065). However, the HR became significant after those individuals with diabetes were excluded (HR 2.60, 95% CI: 1.12\u20106.01, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Screen\u2010detected gallstone disease may predict the risk for liver and pancreatic cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14456","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T13:20:38Z","timestamp":1586179238000},"page":"1744-1755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Screen\u2010detected gallstone disease and risk of liver and pancreatic cancer: The Kailuan Cohort Study"],"prefix":"10.1111","volume":"40","author":[{"given":"Xinyu","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of cardiology the second hospital of Qinhuangdao Qinhuangdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kailuan General Hospital Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics 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