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However, the global epidemiology of HEV infection has not been comprehensively assessed. This study aims to map the global prevalence and identify the risk factors of HEV infection by performing a systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic searching of articles published in Medline, Embase, Web of science, Cochrane and Google scholar databases till July 2019 was conducted to identify studies with HEV prevalence data. Pooled prevalence among different countries and continents was estimated. HEV IgG seroprevalence of subgroups was compared and risk factors for HEV infection were evaluated using odd ratios (OR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 419 related studies which comprised of 1\u00a0519\u00a0872 individuals. A total of 1\u00a0099\u00a0717 participants pooled from 287 studies of general population estimated a global anti\u2010HEV IgG seroprevalence of 12.47% (95% CI 10.42\u201014.67;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a0100%). Notably, the use of ELISA kits from different manufacturers has a substantial impact on the global estimation of anti\u2010HEV IgG seroprevalence. The pooled estimate of anti\u2010HEV IgM seroprevalence based on 98 studies is 1.47% (95% CI 1.14\u20101.85;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a099%). The overall estimate of HEV viral RNA\u2010positive rate in general population is 0.20% (95% CI 0.15\u20100.25;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a098%). Consumption of raw meat (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0001), exposure to soil (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001), blood transfusion (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0138), travelling to endemic areas (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0244), contacting with dogs (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0416), living in rural areas (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0349) and receiving education less than elementary school (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001) were identified as risk factors for anti\u2010HEV IgG positivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Globally, approximately 939\u00a0million corresponding to 1 in 8 individuals have ever experienced HEV infection. 15\u2010110\u00a0million individuals have recent or ongoing HEV infection. Our study highlights the substantial burden of HEV infection and calls for increasing routine screening and preventive measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.14468","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T07:20:22Z","timestamp":1586762422000},"page":"1516-1528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":255,"title":["The global epidemiology of hepatitis E virus infection: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"40","author":[{"given":"Pengfei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC\u2010University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaye","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus 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