{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:06:08Z","timestamp":1789193168434,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies on hepatitis C cascade of care have been mainly focused on diagnosis and treatment rate, while less attention has been given to patients lost to follow\u2010up (LTFU) after diagnosis. Analyses of this latter issue on population level are missing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this nationwide study of people with HCV, we aimed to estimate the proportion LTFU after HCV diagnosis, characterize them, and analyze their other healthcare contacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with chronic HCV in the Swedish National Patient Register during 2001\u20102011 and still alive December 31, 2013, were included. The number of cured patients without need of follow\u2010up was estimated. Visits to HCV specialist care during 2012\u20102013 were analysed. For those LTFU, other specialist care contacts were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total 29\u00a0217 patients were included, with 24\u00a0733 with need of HCV care. 61% (n\u00a0=\u00a015\u00a0007) of them were LTFU from HCV care in 2012\u20102013 and 58% did not attend HCV care during the second year after HCV diagnosis. The departments of surgery\/orthopaedic or psychiatry\/dependency were the most common other non\u2010primary healthcare contacts. Predictors for LTFU were young age, male sex, low education, presence of psychiatric\/dependency diagnosis, unmarried and longer duration since diagnosis of HCV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that almost two\u2010thirds of patients were LTFU after HCV diagnosis, with frequent occurrence early after diagnosis. Efforts to link patients back to HCV care, in combination with early and easy access to HCV treatment and harm reduction, are necessary to reach the HCV elimination goal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14469","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T18:15:23Z","timestamp":1586974523000},"page":"1832-1840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Frequent loss to follow\u2010up after diagnosis of hepatitis C virus infection: A barrier towards the elimination of hepatitis C virus"],"prefix":"10.1111","volume":"40","author":[{"given":"Soo","family":"Aleman","sequence":"first","affiliation":[{"name":"Department of Medicine Huddinge Karolinska Institutet Stockholm Sweden"},{"name":"Department of Infectious Diseases Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7810-3005","authenticated-orcid":false,"given":"Jonas","family":"S\u00f6derholm","sequence":"additional","affiliation":[{"name":"AbbVie AB Stockholm Sweden"},{"name":"Division of Clinical Microbiology Department of Laboratory Medicine Karolinska Institutet at Karolinska University Hospital Huddinge Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"B\u00fcsch","sequence":"additional","affiliation":[{"name":"AbbVie AB Stockholm Sweden"},{"name":"Division of Clinical Microbiology Department of Laboratory Medicine Karolinska Institutet at Karolinska University Hospital Huddinge Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"K\u00f6vamees","sequence":"additional","affiliation":[{"name":"AbbVie AB Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-0910","authenticated-orcid":false,"given":"Ann\u2010Sofi","family":"Duberg","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.10.009"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization.Global hepatitis report 2017.http:\/\/www.who.int\/hepatitis\/publications\/global\u2010hepatitis\u2010report2017\/en\/. 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