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However, less is known about how changes in liver fat associate with the progression of cardiovascular risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A substudy (n\u00a0=\u00a0808) drawn from the Framingham Heart Study underwent serial computed tomography scans 6\u00a0years apart. We performed multivariable\u2010adjusted regression to determine the association between changes in liver fat and progression of cardiovascular risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Each standard deviation increase in liver fat was associated with adverse progression of systolic blood pressure, diastolic blood pressure, fasting glucose, high\u2010density lipoprotein and log triglycerides. After adjusting for baseline cardiovascular risk, baseline\u00a0body mass index (BMI),\u00a0and change in BMI, increasing liver fat was significantly associated with adverse changes in fasting glucose and triglycerides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a longitudinal cohort, increasing liver fat over 6\u00a0years was associated with progression of cardiovascular risk factors, even after accounting for BMI changes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14472","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T09:23:48Z","timestamp":1587115428000},"page":"1339-1343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Increasing liver fat is associated with progression of cardiovascular risk factors"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6215-2435","authenticated-orcid":false,"given":"Katherine T.","family":"Brunner","sequence":"first","affiliation":[{"name":"Section of Gastroenterology Boston Medical Center Boston University School of Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Pedley","sequence":"additional","affiliation":[{"name":"National Heart, Lung, and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study Framingham MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-4812","authenticated-orcid":false,"given":"Joseph M.","family":"Massaro","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics Boston University Boston MA 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