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We conducted a population\u2010based cohort study on the incidence and mortality of autoimmune hepatitis in England, 1997\u20102015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the Clinical Practice Research Datalink we included 882 patients diagnosed with autoimmune hepatitis in England, 1997\u20102015. The patients were followed through 2015, and we calculated the sex\u2010 and age\u2010standardized incidence and prevalence of autoimmune hepatitis. We examined variation in incidence by sex, age, calendar year, geographical region and socioeconomic status, and incidence rate ratios were calculated with Poisson regression. We calculated all\u2010cause and cause\u2010specific mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall standardized incidence rate of autoimmune hepatitis was 2.08 (95% confidence interval 1.94\u20102.22) per 100,000 population per year, higher in women, higher in older age and independent of region and socioeconomic status. From 1997 to 2015 the incidence doubled from 1.27 (95% confidence interval 0.51\u20102.02) to 2.56 (95% confidence interval 1.79\u20103.33) per 100,000 population per year. The 10\u2010year cumulative all\u2010cause mortality was 31.9% (95% confidence interval 27.6\u201036.5), and the 10\u2010year cumulative liver\u2010related mortality, including hepatocellular carcinoma was ~10.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This population\u2010based study showed that the incidence of autoimmune hepatitis doubled over an eighteen\u2010year period. The incidence was particularly high in older women and was similar across all regions of England and independent of socioeconomic status. Patients with autoimmune hepatitis had a high mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14480","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T16:34:00Z","timestamp":1587227640000},"page":"1634-1644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Incidence, prevalence and mortality of autoimmune hepatitis in England 1997\u20102015. 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