{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:51:33Z","timestamp":1782186693901,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T00:00:00Z","timestamp":1590796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Although ursodeoxycholic acid (UDCA) is a first\u2010line treatment for primary biliary cholangitis (PBC), 20%\u201030% of patients with PBC exhibit an incomplete response to UDCA. Recently, the UDCA Response Score was proposed for predicting response to UDCA using pretreatment parameters in patients with PBC. We aimed to validate the UDCA Response Score in Japanese patients with PBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Registry data of Japanese patients (n\u00a0=\u00a0873) were collected. Patients with data on all clinical parameters required for calculating the UDCA Response Score were selected. The endpoint was UDCA response, defined as alkaline phosphatase &lt;1.67 times the upper limit of the normal value after 12\u00a0months of UDCA treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All parameters were available in 804 patients (male\/female\u00a0=\u00a0120\/684, age 58.9 [interquartile range 51.1\u201066.9] years). Bezafibrate was commenced within 12\u00a0months of UDCA in 78 patients (9.7%) because of the lack of an early response. We found that the endpoint was not reached in these 78 patients, and the area under the receiver operating characteristic curve (AUROC) of the score was 0.74 (95% confidence interval [CI] 0.70\u20100.79). The AUROC was 0.77 (95% CI 0.70\u20100.83) in patients undergoing UDCA monotherapy (n\u00a0=\u00a0726). Finally, the AUROC of the modified UDCA Response Score using only data from the treatment start date was 0.80 (95% CI 0.70\u20100.90) in patients receiving a combination therapy of UDCA and bezafibrate (n\u00a0=\u00a0160).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The validity of the UDCA Response Score was acceptable in Japanese patients; this score will be informative in patients treated with a combination therapy of UDCA and bezafibrate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14534","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T22:48:32Z","timestamp":1590101312000},"page":"1926-1933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A validation study of the Ursodeoxycholic Acid Response Score in Japanese patients with primary biliary cholangitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Minami","family":"Yagi","sequence":"first","affiliation":[{"name":"Department of Medicine Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Medicine Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsumasa","family":"Komori","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization (NHO) Nagasaki Medical Center Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoaki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Teishin Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie","family":"Inao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Faculty of Medicine Saitama Medical University Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-5318","authenticated-orcid":false,"given":"Tadashi","family":"Namisaki","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine Nara Medical University Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4986-8578","authenticated-orcid":false,"given":"Kazuhito","family":"Kawata","sequence":"additional","affiliation":[{"name":"Hepatology Division Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Hepatology Graduate School of Medicine Osaka City University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0568-8361","authenticated-orcid":false,"given":"Atsushi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Hon","family":"Kang","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine Oita University Yufu City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-9654","authenticated-orcid":false,"given":"Satoru","family":"Joshita","sequence":"additional","affiliation":[{"name":"Division of Hepatology and Gastroenterology Department of Medicine Shinshu University School of Medicine Matsumoto 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University Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Minoh City Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamato","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Medicine Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Medicine Teikyo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiko","family":"Aiso","sequence":"additional","affiliation":[{"name":"Department of Medicine Teikyo University School of Medicine Tokyo 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology Kagawa University School of Medicine Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-919X","authenticated-orcid":false,"given":"Takeji","family":"Umemura","sequence":"additional","affiliation":[{"name":"Division of Hepatology and Gastroenterology Department of Medicine Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Honda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Tokyo Medical University Ibaraki Medical Center Ibaraki 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