{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T11:01:52Z","timestamp":1770548512069,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Hepatitis C virus (HCV) has high genetic diversity with six major genotypes (GT) GT1\u20106 and global distribution. HCV GT5 and 6 are rare with\u00a0&lt;\u00a010\u00a0million people infected worldwide. Data on direct\u2010acting antiviral use in these rare HCV genotypes are limited. The study aimed to evaluate the efficacy and safety of glecaprevir\/pibrentasvir (G\/P) in a pooled analysis of phase 2\/3 trials in HCV GT5 or 6\u2010infected patients without cirrhosis or with compensated cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with chronic HCV GT5 or 6 infection received oral G\/P (300\u00a0mg\/120\u00a0mg) once daily for 8 or 12\u00a0weeks. The primary efficacy endpoint was sustained virological response at post\u2010treatment week 12 (SVR12) in the intention\u2010to\u2010treat population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred eighty\u2010one patients were evaluated; 56 with HCV GT5 and 125 with HCV GT6. The majority were treatment\u2010na\u00efve (88%) and non\u2010cirrhotic (85%). Overall SVR12 rate with 8\u2010 or 12\u2010week G\/P treatment was 98% (178\/181). Eight\u2010week treatment with G\/P yielded SVR12 rates of 95% (21\/22) in HCV GT5\u2010 and 99% (69\/70) in HCV GT6\u2010infected non\u2010cirrhotic patients. Eight\u2010 and 12\u2010week treatment of patients with compensated cirrhosis achieved SVR12 rates of 100% (10\/10) and 94% (17\/18) respectively. The G\/P regimen was well\u2010tolerated; 3% (6\/181) Grade 3 or higher adverse events, and no serious adverse events were attributed to G\/P or led to study drug discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This integrated dataset demonstrates a high SVR12 rate following 8\u2010week G\/P treatment in patients with HCV GT5 (96%) or GT6 (99%) infection without cirrhosis or with compensated cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14535","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T20:38:41Z","timestamp":1590266321000},"page":"2385-2393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of glecaprevir\/pibrentasvir in patients with HCV genotype 5\/6: An integrated analysis of phase 2\/3 studies"],"prefix":"10.1111","volume":"40","author":[{"given":"Betty B.","family":"Yao","sequence":"first","affiliation":[{"name":"AbbVie Inc North Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda M.","family":"Fredrick","sequence":"additional","affiliation":[{"name":"AbbVie Inc North Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretja","family":"Schnell","sequence":"additional","affiliation":[{"name":"AbbVie Inc North Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris V.","family":"Kowdley","sequence":"additional","affiliation":[{"name":"Elson S. Floyd College of Medicine Washington State University Spokane WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Y.","family":"Kwo","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Poordad","sequence":"additional","affiliation":[{"name":"The Texas Liver Institute University of Texas Health San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"National Hospital for Tropical Diseases Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel S.","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"George","sequence":"additional","affiliation":[{"name":"AZ Groeninge Campus Kennedylaan Kortrijk Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-8869","authenticated-orcid":false,"given":"Florence","family":"Wong","sequence":"additional","affiliation":[{"name":"Toronto General Hospital University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4086-7955","authenticated-orcid":false,"given":"Edward","family":"Gane","sequence":"additional","affiliation":[{"name":"Auckland Clinical Studies Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armand","family":"Abergel","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Estaing Clermont Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine W.","family":"Spearman","sequence":"additional","affiliation":[{"name":"Division of Hepatology Department of Medicine Faculty of Health Sciences University of Cape Town and Groote Schuur Hospital Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Alvarado Hospital Medical Center San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manh","family":"Hung Le","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases Ho Chi Minh Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy TT.","family":"Pham","sequence":"additional","affiliation":[{"name":"Hoa Hao Medic Company Ltd Ho Chi Minh Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Mensa","sequence":"additional","affiliation":[{"name":"AbbVie Inc North Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-0595","authenticated-orcid":false,"given":"Tarik","family":"Asselah","sequence":"additional","affiliation":[{"name":"Department of Hepatology Centre de Recherche sur l\u2019Inflammation INSERM UMR 1149 Universit\u00e9 Paris Diderot AP\u2010HP H\u00f4pital Beaujon Clichy France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.157313"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30045-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.11.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27259"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02538.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02540.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23399"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26744"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15100"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.037"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12896"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13027"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12423"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13324"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30496-6"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30046"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy220"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.09.027"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704053"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.007"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.039"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30341-8"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12721"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02205-18"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.02.057"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719107309120"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15043"},{"key":"e_1_2_10_31_1","unstructured":"AbbVie.MAVIRET (SmPC); AbbVie 2019\/Mavyret (US package insert).2019."},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1177"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512610"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00529-0"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.063"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.047"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.11.011"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15222"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.14535","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T15:06:40Z","timestamp":1693753600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.14535"}},"subtitle":[],"editor":[{"given":"Gregory","family":"Dore","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,11]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/liv.14535"],"URL":"https:\/\/doi.org\/10.1111\/liv.14535","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,11]]},"assertion":[{"value":"2020-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}