{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:38:19Z","timestamp":1790854699048,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Achieving sustained virological response (SVR; cure) in hepatitis C patients using a simple regimen is key to making elimination by 2030 possible. In the largest real\u2010world analysis to date, the effectiveness of pangenotypic, panfibrotic, single\u2010tablet, sofosbuvir\/velpatasvir (SOF\/VEL) once\u2010daily for 12\u00a0weeks was assessed in 12 clinical real\u2010world cohorts from various geographical areas, settings and treatment practices. Factors affecting risk of not achieving SVR were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults treated with SOF\/VEL 400\/100\u00a0mg, without ribavirin, were included. All HCV patients reaching Week 12 or 24 post\u2010treatment were assessed for SVR12\/24. Factors associated with not achieving SVR12\/24 for virological reasons were evaluated using logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 5552 patients were included: 13.3% treatment\u2010experienced; 20.7% compensated cirrhotic; 30.2% genotype 1; 29.5% genotype 2; 32.9% genotype 3; 4.7% genotype 4; 3.7% HIV coinfection; 13.4% current\/former intravenous drug use. Of the 5196 patients evaluated for effectiveness, 98.9% achieved SVR12\/24. High SVR12\/24 rates occurred in all genotypes including genotype 3 (98.3%; 1649\/1677) and in those with compensated cirrhosis (97.9; 1055\/1078). Only 55 patients did not achieve SVR12\/24 due to a virological reason; the only factor statistically significantly associated with an increased risk of not achieving SVR12\/24 was compensated cirrhosis (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002). Overall, 6% (332\/5552) of patients did not achieve SVR12\/24 for non\u2010virological reasons (67% lost to follow\u2010up; 26.5% early treatment discontinuation).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large cohort, representative of clinical practice, a simple 12\u2010week regimen of SOF\/VEL without ribavirin resulted in high SVR12\/24 rates in diverse patient populations, even among those with compensated cirrhosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.14537","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T13:30:27Z","timestamp":1590413427000},"page":"1841-1852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Global real\u2010world evidence of sofosbuvir\/velpatasvir as simple, effective HCV treatment: Analysis of 5552 patients from 12 cohorts"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2600-3555","authenticated-orcid":false,"given":"Alessandra","family":"Mangia","sequence":"first","affiliation":[{"name":"IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Milligan","sequence":"additional","affiliation":[{"name":"Trio Health Analytics La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-9139","authenticated-orcid":false,"given":"Mandana","family":"Khalili","sequence":"additional","affiliation":[{"name":"University of California San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fagiuoli","sequence":"additional","affiliation":[{"name":"Papa Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Shafran","sequence":"additional","affiliation":[{"name":"University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Carrat","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM Institut Pierre Louis Epid\u00e9miologie et Sant\u00e9 Publique APHP.Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Ouzan","sequence":"additional","affiliation":[{"name":"Institut Arnault Tzanck Saint\u2010Laurent\u2010du\u2010Var France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3518-4060","authenticated-orcid":false,"given":"George","family":"Papatheodoridis","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alnoor","family":"Ramji","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio M.","family":"Borgia","sequence":"additional","affiliation":[{"name":"William Osler Health System Brampton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-0480","authenticated-orcid":false,"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"University Clinic Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggero","family":"Losappio","sequence":"additional","affiliation":[{"name":"Vittorio Emanuele II Hospital Bisceglie Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"P\u00e9rez\u2010Hernandez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Nuestra Se\u00f1ora de Candelaria Santa Cruz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Wick","sequence":"additional","affiliation":[{"name":"Trio Health Analytics La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Robert S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine Department of Medicine New York City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-7476","authenticated-orcid":false,"given":"Pietro","family":"Lampertico","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Doucette","sequence":"additional","affiliation":[{"name":"University of Alberta Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Ntalla","sequence":"additional","affiliation":[{"name":"Gilead Sciences Europe Ltd Stockley Park United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heribert","family":"Ramroth","sequence":"additional","affiliation":[{"name":"Gilead Sciences Europe Ltd Stockley Park United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mertens","sequence":"additional","affiliation":[{"name":"Gilead Sciences Europe Ltd Stockley Park United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Vanstraelen","sequence":"additional","affiliation":[{"name":"Gilead Sciences Europe Ltd Stockley Park United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Turnes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology C.H.U. Pontevedra and IIS Galicia Sur Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Global health sector strategy on viral hepatitis 2016\u20132021: towards ending viral hepatitis.2016.https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/246177\/WHO\u2010HIV\u20102016.06\u2010eng.pdf?sequence=1. Accessed April 2020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32111-1"},{"key":"e_1_2_9_6_1","unstructured":"World Health Organization.Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection.2018.https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/273174\/9789241550345\u2010eng.pdf?ua=1. Accessed April 2020"},{"key":"e_1_2_9_7_1","first-page":"e625","article-title":"SAT\u2010260\u2010Global timing of hepatitis C virus elimination: estimating the year countries will achieve the World Health Organization elimination targets","volume":"70","author":"Ravazi H","year":"2019","journal-title":"J Hepatol"},{"key":"e_1_2_9_8_1","unstructured":"American Association for the Study of Liver Diseases.HCV guidance: AASLD\u2010IDSA recommendations for testing managing and treating adults infected with hepatitis C virus.https:\/\/www.hcvguidelines.org\/. Accessed April 2020"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"1","article-title":"A simplified algorithm for the management of hepatitis C infection","volume":"5","author":"Dieterich D","year":"2019","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.09.019"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214795"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512610"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512612"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512614"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix260"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215783"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8040313"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15043"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-019-1184-y"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14592"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-018-1066-8"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3908767"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001233"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32060-7"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.047"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.032"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30404-1"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2018.08.013"},{"key":"e_1_2_9_30_1","unstructured":"Association Fran\u00e7aise pour l\u2019\u00e9tude du foie.Recommandations AFEF pour l'\u00e9limination de l'infection par le virus\u00a0de l'h\u00e9patite\u00a0C en France.2018.https:\/\/afef.asso.fr\/wp\u2010content\/uploads\/2018\/06\/VF\u2010INTERACTIF\u2010RECO\u2010VHC\u2010AFEF\u2010v2103.pdf. Accessed April 2020"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25058"},{"key":"e_1_2_9_32_1","unstructured":"American Association for the Study of the Liver.Viral hepatitis elimination: call to action.https:\/\/www.aasld.org\/programs\u2010initiatives\/viral\u2010hepatitis\u2010elimination\u2010call\u2010action. Accessed April 2020"},{"issue":"1","key":"e_1_2_9_33_1","first-page":"360A","article-title":"606\u2010Effectiveness of Sofosbuvir\/Velpatasvir for 12 Weeks in HCV Genotype 3 Patients with Compensated Cirrhosis in Clinical Practice Cohorts from Around the World","volume":"68","author":"Fagiuoli S","year":"2018","journal-title":"Hepatology"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.06.042"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199174"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0969-3"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.14537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.14537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:26:12Z","timestamp":1693891572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.14537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/liv.14537"],"URL":"https:\/\/doi.org\/10.1111\/liv.14537","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]},"assertion":[{"value":"2020-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}