{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T02:58:57Z","timestamp":1771210737873,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The common missense sequence variants of methylenetetrahydrofolate reductase (<jats:italic>MTHFR<\/jats:italic>), rs1801131 (c.A1298C) and rs1801133 (c.C677T), favour the development of hyperhomocysteinemia and diminished DNA methylation. Previous studies, carried out in small series and with suboptimal characterization of the hepatic phenotype, tested the association of these genetic variants with fatty liver disease (FLD), with conflicting results. Here, we assessed the association of rs1801131 and rs1801133 with hepatic phenotype in the Liver Biopsy Cross\u2010Sectional Cohort, a large cohort (n=1375 from Italy and 411 from Finland) of European individuals with suspect FLD associated with dysmetabolism. A total of 1786 subjects were analysed by ordinal regression analyses. The rs1801131 and the rs1801133 variants were not associated with steatosis, inflammation, ballooning or fibrosis. The present study suggests that changes in folate and methionine metabolism resulting from these 2 variants are not associated with a clinically significant impact on FLD in Europeans.<\/jats:p>","DOI":"10.1111\/liv.14543","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T23:03:56Z","timestamp":1590620636000},"page":"1934-1940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Genetic variants in the MTHFR are not associated with fatty liver disease"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-0500","authenticated-orcid":false,"given":"Antonio","family":"De Vincentis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Geriatrics University Campus Bio\u2010Medico of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1126-3071","authenticated-orcid":false,"given":"Rosellina Margherita","family":"Mancina","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6241-6859","authenticated-orcid":false,"given":"Jussi","family":"Pihlajam\u00e4ki","sequence":"additional","affiliation":[{"name":"Clinical Nutrition and Obesity Center Kuopio University Hospital Kuopio Finland"},{"name":"Department of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0735-400X","authenticated-orcid":false,"given":"Ville","family":"M\u00e4nnist\u00f6","sequence":"additional","affiliation":[{"name":"Department of Medicine 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