{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:48:56Z","timestamp":1789192136387,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Liver fibrosis assessed by liver biopsy is predictive of clinical liver events in patients with nonalcoholic fatty liver disease (NAFLD). Magnetic resonance elastography (MRE) correlates with liver biopsy in assessing liver fibrosis. However, data assessing the relationship between MRE and clinical liver events are lacking. We investigated the association between MRE and clinical liver events\/death and identified the cut\u2010off to predict clinical liver events in NAFLD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicenter retrospective study of NAFLD patients who underwent MRE between 2016 and 2019. Clinical liver events were defined as decompensation events and death. We categorized patients into noncirrhosis, compensated cirrhosis and decompensated cirrhosis. Fisher's exact test was used to test association strength. Receiver operative curve methods were used to determine the optimal cut\u2010off of MRE liver stiffness and to maximize the accuracy for classifying noncirrhosis, compensated cirrhosis and decompensated cirrhosis. Logistic regression modelling was used to predict decompensation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 320 NAFLD patients who underwent MRE. The best threshold for distinguishing cirrhosis from noncirrhosis was 4.39\u00a0kPa (AUROC 0.92) and from decompensated cirrhosis was 6.48\u00a0kPa (AUROC 0.71). Odds of decompensation increased as liver stiffness increased (OR 3.28) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Increased liver stiffness was associated with ascites, hepatic encephalopathy, oesophageal variceal bleeding and mortality (median 7.10, 10.15 and 10.15\u00a0kPa respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In NAFLD patients, liver stiffness measured by MRE with a cut\u2010off of \u22656.48\u00a0kPa is associated with decompensation and mortality, and specific MRE cut\u2010offs are predictive of individual clinical liver events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14593","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T19:35:45Z","timestamp":1594496145000},"page":"2242-2251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["MR elastography\u2010based liver fibrosis correlates with liver events in nonalcoholic fatty liver patients: A multicenter study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2740-2486","authenticated-orcid":false,"given":"Ma Ai Thanda","family":"Han","sequence":"first","affiliation":[{"name":"Division of Digestive and Liver Diseases Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarshi","family":"Vipani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Noureddin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Nevada Las Vegas NV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Fatty Liver Program Division of Digestive and Liver Diseases Comprehensive Transplant Program Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Gornbein","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of California at Los Angeles Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola","family":"Saouaf","sequence":"additional","affiliation":[{"name":"Department of Imaging Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Baniesh","sequence":"additional","affiliation":[{"name":"Department of Imaging Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oladuni","family":"Cummings\u2010John","sequence":"additional","affiliation":[{"name":"Division of Liver Texas Liver Institute San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toluwalase","family":"Okubote","sequence":"additional","affiliation":[{"name":"Division of Liver Texas Liver Institute San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica Wendy","family":"Setiawan","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7549-8216","authenticated-orcid":false,"given":"Yaron","family":"Rotman","sequence":"additional","affiliation":[{"name":"Liver &amp; 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