{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:54:57Z","timestamp":1758704097831,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver impairment is frequent in patients with novel coronavirus disease (COVID\u201019) and direct viral tropism for the liver has been proven. Since several of the currently administered drugs against severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) are possibly hepatotoxic, the management of patients with COVID\u201019 and liver failure is still an almost unexplored field. Taking this challenging case of acute HBV with persistent hyperbilirubinemia and SARS\u2010COV\u20102 infection with respiratory distress as a starting point, we here loop through this condition. Where the available therapeutic options are scarce, we here propose hemoperfusion (HP) as an attractive alternative to both delay any late\u2010stage progression of hyper inflammation process in COVID\u201019 and remove the toxins involved in acute liver failure.<\/jats:p>","DOI":"10.1111\/liv.14609","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T21:59:37Z","timestamp":1595023177000},"page":"2655-2659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Running out of bullets: The challenging management of acute hepatitis and SARS\u2010COV\u20102 from the SMatteo COvid19 Registry (SMACORE)"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-9576","authenticated-orcid":false,"given":"Marta","family":"Colaneri","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases I Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Valsecchi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases I Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Perotti","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Emergency Department Fondazione IRCCS Policlinico S. Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Ludovisi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases I Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Seminari","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases I Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa Chiara","family":"Pieri","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases I Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Sacchi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases I Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0235-9207","authenticated-orcid":false,"given":"Raffaele","family":"Bruno","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases I Fondazione IRCCS Policlinico San Matteo Pavia Italy"},{"name":"Department of Clinical, Surgical, Diagnostic, and Paediatric Sciences University of Pavia Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_4_6_1","article-title":"Clinical characteristics of imported cases of COVID\u201019 in Jiangsu Province: a multicenter descriptive study","author":"Wu J","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"2","key":"e_1_2_4_7_1","first-page":"100","article-title":"Exploring the mechanism of liver enzyme abnormalities in patients with novel coronavirus\u2010infected pneumonia","volume":"28","author":"Guan GW","year":"2020","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"2","key":"e_1_2_4_8_1","first-page":"107","article-title":"Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study","volume":"28","author":"Liu C","year":"2020","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14449"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14435"},{"key":"e_1_2_4_11_1","article-title":"Clinical characteristics of hospitalized patients with SARS\u2010CoV\u20102 and hepatitis B virus co\u2010infection","author":"Chen X","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_4_13_1","article-title":"Characteristics of liver function in patients with SARS\u2010CoV\u20102 and chronic HBV co\u2010infection","author":"Zou X","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_4_15_1","article-title":"Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019\u2010nCoV Infection","author":"Chai X","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_4_16_1","first-page":"1","article-title":"COVID\u201019: abnormal liver function tests","author":"Cai Q","year":"2020","journal-title":"J Hepatol"},{"issue":"6","key":"e_1_2_4_17_1","first-page":"e8645","article-title":"COVID\u201019 induced hepatitis B virus reactivation: a novel case from the United Arab Emirates","volume":"12","author":"Aldhaleei WA","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_4_18_1","unstructured":"CouttsER.Evaluation of adsorbent haemoperfusion in interventional therapy of sepsis. PQDT \u2010 UK & Ireland.2016."}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.14609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.14609","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T16:09:28Z","timestamp":1693670968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.14609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/liv.14609"],"URL":"https:\/\/doi.org\/10.1111\/liv.14609","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"type":"print","value":"1478-3223"},{"type":"electronic","value":"1478-3231"}],"subject":[],"published":{"date-parts":[[2020,8,6]]},"assertion":[{"value":"2020-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}