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Our aim was to compare these tests\u2019 prognostic value in a cohort of patients with compensated chronic liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with unselected compensated liver disease aetiologies had baseline assessments and were followed up for development of clinical outcomes, blinded to the imaging results. The prognostic value of non\u2010invasive liver tests at prespecified thresholds was assessed for a combined clinical endpoint comprising ascites, variceal bleeding, hepatic encephalopathy, hepatocellular carcinoma, liver transplantation and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and ninety\u2010seven patients (61% male) with median age of 54\u00a0years were followed up for 693 patient\u2010years (median (IQR) 43 (26\u201058) months). The main diagnoses were NAFLD (41%), viral hepatitis (VH, 25%) and alcohol\u2010related liver disease (ArLD; 14%). During follow\u2010up 14 new clinical events, and 11 deaths occurred. Clinical outcomes were predicted by liver cT<jats:sub>1<\/jats:sub>\u00a0&gt;\u00a0825ms with HR 9.9 (95% CI: 1.29\u201076.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007), TE\u00a0&gt;\u00a08kPa with HR 7.8 (95% CI: 0.97\u201062.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) and FIB\u20104\u00a0&gt;\u00a01.45 with HR 4.09 (95% CI: 0.90\u201018.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.05). In analysis taking into account technical failure and unreliability, liver cT<jats:sub>1<\/jats:sub>\u00a0&gt;\u00a0825\u00a0ms could predict clinical outcomes (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), but TE\u00a0&gt;\u00a08kPa could not (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We provide further evidence that liver cT<jats:sub>1<\/jats:sub>, TE and serum\u2010based biomarkers can predict clinical outcomes, but when taking into account technical failure\/unreliability, TE cut\u2010offs perform worse than those of cT<jats:sub>1<\/jats:sub> and blood biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14625","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T04:03:32Z","timestamp":1596168212000},"page":"3071-3082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Prognostic value of multiparametric magnetic resonance imaging, transient elastography and blood\u2010based fibrosis markers in patients with chronic liver disease"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3272-2695","authenticated-orcid":false,"given":"Arjun N. 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