{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:16:14Z","timestamp":1783430174500,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>This prospective observational study aimed to evaluate the best serum and urine markers to assess predictability for the prognosis of patients with decompensated cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum creatinine and cystatin C (CysC), and urinary N\u2010acetyl\u2010beta\u2010D glucosaminidase (uNAG) and neutrophil gelatinase\u2010associated lipocalin (uNGAL) levels were measured from hospitalized patients with decompensated cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 328 patients (mean age, 57.2\u00a0\u00b1\u00a012.0\u00a0years; 237 men) with decompensated cirrhosis were included. Alcoholic liver disease was the most frequent underlying liver disease (68.0%). Acute kidney injury (AKI) was concomitantly present in 41 patients (12.5%) at baseline. INR, serum creatinine and CysC levels, and uNAG and uNGAL levels were significantly higher in patients with AKI. During hospitalization, AKI had progressed in 37 patients (11.3%). In 287 patients without AKI, the incidence of AKI at 3, 6, 9 and 12\u00a0months was 15.4%, 22.2%, 28.6% and 32.5% respectively. On multivariate analysis, serum CysC and uNAG levels were independent predictors of AKI, and their optimal cut\u2010off values were 1.055\u00a0mg\/L and 23.1\u00a0U\/g urinary Cr respectively. When patients were classified into three groups with these cut\u2010off values of serum CysC and uNAG levels (group 1, both low; group 2, one of two high; and group 3, both high), progression of AKI during hospitalization (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), incidence of AKI in patients without AKI at baseline (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and mortality rate (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) differed significantly according to serum CysC and uNAG levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum CysC and uNAG levels are useful prognostic markers for renal outcomes and mortality in patients with decompensated cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14631","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T21:21:39Z","timestamp":1596576099000},"page":"3083-3092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prognosis predictability of serum and urine renal markers in patients with decompensated cirrhosis: A multicentre prospective study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-4293","authenticated-orcid":false,"given":"Tae Hyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Korea University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8049-0956","authenticated-orcid":false,"given":"Yeon Seok","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea 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