{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:42:01Z","timestamp":1788914521382,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004147","name":"Tsinghua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005347","name":"American Association for the Study of Liver Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aim<\/jats:title><jats:p>An affordable, pangenotypic regimen remains as an unmet medical need for chronic hepatitis C patients in China. This single\u2010arm, open\u2010label, multicenter, phase 3 trial evaluated the efficacy and safety of coblopasvir, a pangenotypic non\u2010structural protein 5A (NS5A) inhibitor, combined with sofosbuvir for treating Chinese patients with chronic hepatitis C virus (HCV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Treatment\u2010na\u00efve and interferon\u2010experienced adult patients, including those with advanced fibrosis (F3) or compensated cirrhosis (F4), were treated with a universal, combinational regimen of coblopasvir 60\u00a0mg and sofosbuvir 400\u00a0mg, once daily, for 12\u00a0weeks. The primary efficacy endpoint was sustained virological response at post\u2010treatment week 12 (SVR12).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 371 patients (men, 51%; age, 47\u00a0\u00b1\u00a011\u00a0years; genotype 1a\u00a0&lt;\u00a01%, 1b 48%, 2a 26%, 3a 6%, 3b 7% and 6 12%) were enrolled from 19 sites. Fifty\u2010one patients (14%) had F3, 39 patients (11%) had F4 and 39 patients (11%) were interferon experienced. The overall SVR12 was 97% (95% CI, [94%, 98%]) for the full analysis set and was equal to or above 90% for all predefined subsets. Ten patients (3%) experienced virological relapse and two patients did not complete follow\u2010up. No adverse events (AEs) occurred at a frequency \u22655%, and the most often reported AEs (\u22651%) were neutropenia and fatigue. The majority of AEs were mild to moderate and transient without specific medical intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The universal, pangenotypic combo of coblopasvir plus sofosbuvir is an efficacious and safe treatment for Chinese patients monoinfected with HCV of genotype 1, 2, 3 and 6, including those with compensated cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay summary<\/jats:title><jats:p>The regimen of coblopasvir and sofosbuvir is a safe and effective treatment for Chinese patients with genotype 1, 2, 3 and 6 HCV infection, including those with compensated cirrhosis. Therefore, this regimen would be a novel choice of treatment for this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14633","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T06:34:02Z","timestamp":1596954842000},"page":"2685-2693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Coblopasvir and sofosbuvir for treatment of chronic hepatitis C virus infection in China: A single\u2010arm, open\u2010label, phase 3 trial"],"prefix":"10.1111","volume":"40","author":[{"given":"Yanhang","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Hepatology the First Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Hepatology the First Hospital of Jilin University Changchun 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