{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:17:14Z","timestamp":1784287034724,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009680","name":"Yale Liver Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009680","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>The impact of chronic liver diseases (CLDs) on health\u2010related quality of life (HRQoL) is relevant to understand the burden of these conditions and inform decision\u2010making processes related to their care. Studies simultaneously comparing the HRQoL of patients affected by the major CLDs to that of the general population are still lacking and are the subject of this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the EQ\u20105D\u20103L questionnaire, we analysed and compared HRQoL data from 2962 Italian patients affected by CLDs and forming a representative sample of the general Italian population (6800 individuals). Exploratory analyses were conducted to investigate the effects of each CLD on HRQoL, using the general population as reference and adjusting for possible confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with CLDs (HBV, HCV, PSC, PBC, AIH, NAFLD\/NASH) in the chronic hepatitis stage and with compensated cirrhosis (CC) showed HRQoL similar to the general population. However, AIH were more likely to report problems in self\u2010care and lower EQ\u20105D VAS score, while NAFLD\/NASH and HCV showed an increased risk of anxiety\/depression. On the other hand, with progression to more advanced stages of liver disease (DC or HCC), HRQoL decreased significantly with higher risk of reporting problems in the physical domains, and significant reductions in the VAS and utility index scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Different subtypes of CLD affected different QoL domains. This study therefore provides a real estimate of the impact of CLDs on patients\u2019 HRQoL, and represents a much needed tool to inform decision\u2010making while assessing the effectiveness and cost\u2010effectiveness of the care of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14647","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T16:59:29Z","timestamp":1599065969000},"page":"2630-2642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Health related quality of life in chronic liver diseases"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5241-4473","authenticated-orcid":false,"given":"Paolo A.","family":"Cortesi","sequence":"first","affiliation":[{"name":"Research Centre on Public Health (CESP) University of Milan\u2010Bicocca Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-3740","authenticated-orcid":false,"given":"Sara","family":"Conti","sequence":"additional","affiliation":[{"name":"Research Centre on Public Health (CESP) University of Milan\u2010Bicocca Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Scalone","sequence":"additional","affiliation":[{"name":"Research Centre on Public Health (CESP) University of Milan\u2010Bicocca Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Liver Center &amp; 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