{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T19:42:40Z","timestamp":1769629360138,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several cohorts have shown that long\u2010term tenofovir\u2010containing combination antiretroviral therapy (cART) leads to higher HBsAg seroclearance rates in HIV\/HBV coinfected patients vs HBV\u2010monoinfected patients under tenofovir disoproxil fumarate (TDF)\u2010based therapy. We have analysed data on determinants of HBsAg loss in a retrospective multicentric cohort of 359 HIV\/HBV coinfected patients. Median CD4 T\u2010cell count at baseline was 359\/ul (321\u2010404), CDC stage was C in 20% (n\u00a0=\u00a070). Most patients (68%) were ART\u2010na\u00efve when TDF\u2010 or tenofovir alafenamide (TAF)\u2010containing cART was initiated (baseline). After a median follow\u2010up of 11\u00a0years HBsAg loss had occurred in 66\/359 (18%) patients. However, patients with stage CDC C (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.001), lower CD4 gain (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.043) and not receiving TDF\/FTC (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008) were less likely to lose HBsAg. Long\u2010term TDF\u2010containing cART appears to achieve higher rates of HBsAg seroclearance compared to published data for HBV monoinfected subjects. However, late presentation for HIV and poor immune recovery significantly impair HBV seroconversion rates.<\/jats:p>","DOI":"10.1111\/liv.14684","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T05:39:57Z","timestamp":1601789997000},"page":"2978-2981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Obstacles to HBV functional cure: Late presentation in HIV and its impact on HBV seroconversion in HIV\/HBV coinfection"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-1084","authenticated-orcid":false,"given":"Kathrin","family":"van Bremen","sequence":"first","affiliation":[{"name":"Bonn University Hospital Bonn Germany"},{"name":"German Centre for Infection Research (DZIF) Bonn\u2010Cologne 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