{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:18Z","timestamp":1787015778398,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>There is emerging data on the use of Sofosbuvir\u2010based directly acting antiviral (DAA) drug regimens in chronic hepatitis C (CHC) patients with end\u2010stage renal disease (ESRD) on maintenance haemodialysis (MHD). We evaluated the safety and efficacy of Sofosbuvir plus Velpatasvir fixed\u2010dose combination in CHC patients with ESRD on MHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010one CHC patients with ESRD on MHD were included in a real\u2010life prospective study. All patients irrespective of genotype; presence of cirrhosis; treatment naive or experienced status were treated with full\u2010dose Sofosbuvir (400\u00a0mg) plus Velpatasvir (100\u00a0mg) fixed\u2010dosed combination given daily for 12\u00a0weeks. The efficacy was assessed by the sustained virological response (SVR12) with negative HCV RNA 12\u00a0weeks after the end of treatment (ETR). Side effects if any were recorded in all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median HCV RNA level in 51 CHC patients [Males 41 (80.4%), mean age 42.8\u00a0\u00b1\u00a014.6\u00a0years] was 2.0\u00a0\u00d7\u00a010\n                      <jats:sup>6<\/jats:sup>\n                      IU\/mL. HCV genotype was available in 19 patients with predominant genotype 1 in 15 (79%) patients. Ten (19.6%) patients had evidence of cirrhosis (defined as LSM\u00a0\u2265\u00a012.5\u00a0kPa on Transient Elastography), and 8 (15.6%) patients were treatment experienced. Testing for ETR was done in 36 patients and all 36 (100%) patients achieved ETR, and 49 patients (96%) achieved SVR 12. All 51 patients tolerated the Sofosbuvir\u00a0+\u00a0Velpatasvir combination, with none of the patients reporting any serious adverse event.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sofosbuvir plus Velpatasvir fixed\u2010dose combination is safe and effective in treating CHC in patients with ESRD on MHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.14685","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T04:41:11Z","timestamp":1602045671000},"page":"705-709","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sofosbuvir and Velpatasvir combination is safe and effective in treating chronic hepatitis C in end\u2010stage renal disease on maintenance haemodialysis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3901-6969","authenticated-orcid":false,"given":"Sunil","family":"Taneja","sequence":"first","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-2664","authenticated-orcid":false,"given":"Ajay","family":"Duseja","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh 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