{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:40:56Z","timestamp":1789656056772,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>A variety of auto\u2010antibody assays are available as part of the clinical care of patients with liver disease. We sought to better understand the clinical utility of immune serological testing in patients with primary biliary cholangitis (PBC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed data from 2846 patients investigated for liver disease at a UK liver centre between 2001 and 2017. A total of 499 patients with PBC were identified. Immune serology results were examined for their diagnostic utility and prognostic significance to predict transplant\u2010free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Antimitochondrial antibodies (AMAs) were specific (94.5%) and sensitive (85.6%) for PBC; antinuclear antibodies (ANAs) against glycoprotein 210 (gp210) and sp100 were specific (&gt;98%) but not sensitive (&lt;25%). The disease\u2010specific ANAs were detectable in 29.6% of AMA\u2010negative patients. Anti\u2010gp210 auto\u2010antibodies were significantly associated with elevated serum aminotransferase activity, bilirubin and liver stiffness at presentation (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.010). Anti\u2010gp210 auto\u2010antibodies predicted non\u2010response to ursodeoxycholic acid (UDCA) by GLOBE criteria (39.3% vs 16.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.005). Moreover, anti\u2010gp210 was independently associated with death or liver transplantation (HR 3.22, 95% CI 1.49\u20106.96;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003), after accounting for other significant baseline determinants of outcome. Serologic finding of anti\u2010gp210 antibodies conferred an independent risk of death or transplantation (HR 4.13, 95% CI 1.85\u20109.22;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) after accounting for treatment response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our single\u2010centre cohort of patients with PBC, the presence of anti\u2010gp210 was associated with an adverse presenting phenotype, predicted treatment non\u2010response and independently predicted reduced transplant\u2010free survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.14688","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T18:00:25Z","timestamp":1602007225000},"page":"535-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Antibodies to gp210 and understanding risk in patients with primary biliary cholangitis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-8839","authenticated-orcid":false,"given":"Debashis","family":"Haldar","sequence":"first","affiliation":[{"name":"National Institute for Health Research Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham Birmingham UK"},{"name":"Institute of Immunology and Immunotherapy University of Birmingham Birmingham UK"},{"name":"Liver Unit University Hospitals Birmingham NHS Foundation Trust Birmingham 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