{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:08:03Z","timestamp":1783944483144,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Liver stiffness measurements (LSM), commonly performed by transient elastography (TE) or two\u2010dimensional shear wave elastography (2D\u2010SWE), are used to quantify liver fibrosis. Active hepatitis, a hallmark of autoimmune hepatitis (AIH), could bias LSM. This bias might be overcome by measurement spleen 2D\u2010SWE. Here, we compare liver and spleen 2D\u2010SWE to TE and liver biopsy (LB) in prospectively recruited patients with AIH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed liver and spleen 2D\u2010SWE in relation to liver TE in 90 patients treated\u00a0\u2265\u00a06\u00a0months for AIH. Liver and spleen 2D\u2010SWE were also compared to LB in 63 individuals with AIH. Finally, we evaluated these tools in 220 patients with AIH and during 18\u00a0months follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Liver 2D\u2010SWE correlated with surrogate markers of active hepatitis (ALT and IgG, both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) but there was no link between spleen 2D\u2010SWE and ALT. Liver 2D\u2010SWE, but not spleen 2D\u2010SWE, was associated with histopathological inflammatory score (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). When compared to LB, the optimal cut\u2010offs for detecting cirrhosis by liver and spleen 2D\u2010SWE were 16.1\u00a0kPa (AUROC 0.93) and 29.8\u00a0kPa (AUROC 0.95), respectively. In patients with active hepatitis the combined diagnostic approach including liver and spleen 2D\u2010SWE had significantly better AUROC for detecting cirrhosis than liver 2D\u2010SWE alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liver and spleen 2D\u2010SWE are reliable complementary methods for the diagnosis of advanced fibrosis in AIH. Spleen 2D\u2010SWE seems to be less biased by inflammation and could facilitate fibrosis assessment in therapy\u2010na\u00efve patients or in the presence of active hepatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14726","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T17:51:16Z","timestamp":1604771476000},"page":"348-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Measurement of liver and spleen stiffness as complementary methods for assessment of liver fibrosis in autoimmune hepatitis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-0336","authenticated-orcid":false,"given":"Maciej K.","family":"Janik","sequence":"first","affiliation":[{"name":"Liver and Internal Medicine Unit Department of General, Transplant and Liver Surgery Medical University of Warsaw Warsaw Poland"},{"name":"European Reference Network on Hepatological 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