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Disseminated lung injury with the development of acute respiratory distress syndrome (ARDS) is the main cause of mortality in COVID\u201019. Although liver failure does not seem to occur in the absence of pre\u2010existing liver disease, hepatic involvement in COVID\u201019 may correlate with overall disease severity and serve as a prognostic factor for the development of ARDS. The spectrum of liver injury in COVID\u201019 may range from direct infection by SARS\u2010CoV\u20102, indirect involvement by systemic inflammation, hypoxic changes, iatrogenic causes such as drugs and ventilation to exacerbation of underlying liver disease. This concise review discusses the potential pathophysiological mechanisms for SARS\u2010CoV\u20102 hepatic tropism as well as acute and possibly long\u2010term liver injury in COVID\u201019.<\/jats:p>","DOI":"10.1111\/liv.14730","type":"journal-article","created":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T13:20:52Z","timestamp":1605446452000},"page":"20-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":342,"title":["Pathophysiological mechanisms of liver injury in COVID\u201019"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1895-7161","authenticated-orcid":false,"given":"Alexander D.","family":"Nardo","sequence":"first","affiliation":[{"name":"Hans Popper Laboratory of Molecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Schneeweiss\u2010Gleixner","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit 13H1. 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