{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:09:29Z","timestamp":1761664169909,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Renal function is a major determinant of prognosis in patients with cirrhosis. Current guidelines only contemplate serum creatinine (sCr) to assess kidney injury. However, there are formulas to estimate glomerular filtration rate (eGFR) which better measure renal function in patients listed for liver transplantation. There is no data available on whether these formulas predict prognosis in patients with acute kidney injury (AKI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 143 patients presenting with a first episode of AKI, we compared the prognostic value of renal function estimated using sCr or eGFR assessed with Modification of Diet in Renal Disease (MDRD\u20106), chronic kidney disease epidemiology (CKD\u2010EPI) and Royal Free Hospital (RFH) for renal replacement therapy (RRT) within 30\u00a0days of AKI, and 30\u2010 and 90\u2010day transplant\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>eGFR was calculated on values obtained before and at admission, at presentation of AKI (D0) and 48\u00a0hours after AKI (D2).15% of patients (more commonly in alcohol\u00a0+\u00a0metabolic etiology; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.049 vs other) required RRT. Transplant\u2010free survival at 30\u2010and 90\u2010day were 77% and 63%. Among sCr, MDRD\u20106, CKD\u2010EPI and RFH\u2010eGFR, the latter predicted best RRT (HR 0.937 95% CI 0.893\u20100.982, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007), 30\u2010d (HR 0.936 95% CI 0.901\u20100.972, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and 90\u2010d (HR 0.934 95% CI 0.908\u20100.972, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) mortality\/OLT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Renal function estimated using the RFH\u2010eGFR calculated at D2 after AKI diagnosis is a strong predictor of RRT and of 30\u2010d and 90\u2010d transplant\u2010free survival. Results suggest that in cirrhosis, RFH\u2010eGFR may be a better indicator of prognosis in AKI than sCr.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14765","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T13:20:13Z","timestamp":1607952013000},"page":"819-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Royal Free Hospital\u2010estimated glomerular filtration rate for prognostic stratification of first acute kidney injury in cirrhosis"],"prefix":"10.1111","volume":"41","author":[{"given":"Susana G.","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Hepatology Department of Biomedical Research UVCM Bern University Hospital University of Bern Bern Switzerland"},{"name":"Faculty of Medicine of the University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3421-937X","authenticated-orcid":false,"given":"Juan G.","family":"Abraldes","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology (Liver Unit) University of Alberta Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5069-2461","authenticated-orcid":false,"given":"Emmanouil","family":"Tsochatzis","sequence":"additional","affiliation":[{"name":"UCL Institute for Liver and Digestive Health Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[{"name":"Hepatology Department of Biomedical Research UVCM Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4562-9016","authenticated-orcid":false,"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[{"name":"Hepatology Department of Biomedical Research UVCM Bern University Hospital University of Bern Bern 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