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We characterized changes in PROs from pre\u2010treatment to 12\u00a0months post\u2010treatment in a real\u2010world cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PROP UP was a multi\u2010centre observational cohort study of 1601 patients treated with DAAs at 11 US gastroenterology\/hepatology practices from 2015 to 2017. PROs were evaluated pre\u2010treatment (T1) and 12\u00a0months post\u2010treatment (T5). A minimally important change (MIC) threshold was prespecified as &gt;5% change in PRO scores from T1 to T5. Multivariable analyses identified predictors of change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three\u2010quarters of patients were 55 or older; 45% were female, 60% were white, 33% were black, nearly half had cirrhosis. The most commonly\u2010prescribed DAA regimens were sofosbuvir\u2010based (83%) and grazoprevir\/elbasvir (11%). Study retention was &gt;95%. On average, small improvements were observed at 3\u00a0months post\u2010treatment in all PROs and sustained at 12\u00a0months post\u2010treatment among patients with sustained virologic response (SVR). Clinically meaningful improvements were achieved in fatigue (mean change score: \u22123.7 [\u22124.2, \u22123.1]), sleep (mean change score: \u22123.1 [\u22123.7, \u22122.5]), abdominal pain (mean change score: \u22122.6 [\u22123.3, \u22121.9]) and functional well\u2010being (mean change score: \u22127.0 [\u22126.0, \u22128.0]). Symptom improvements were generally not sustained with no SVR (n\u00a0=\u00a052). Patients with cirrhosis and MELD \u226512 had the greatest improvements in functional well\u2010being (\u221212.9 [\u221217.6, \u22128.1]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The improvements in patient\u2010reported outcomes reported by patients who achieved SVR following HCV DAA therapy were durable at 12\u00a0months post\u2010treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14781","type":"journal-article","created":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T14:20:21Z","timestamp":1609597221000},"page":"692-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Patient\u2010reported outcomes 12\u00a0months after hepatitis C treatment with direct\u2010acting antivirals: Results from the PROP UP study"],"prefix":"10.1111","volume":"41","author":[{"given":"Marina","family":"Serper","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-1846","authenticated-orcid":false,"given":"Donna M.","family":"Evon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jipcy","family":"Amador","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souvik","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine University of California at Davis Davis CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna S.","family":"Lok","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-2475","authenticated-orcid":false,"given":"Richard K.","family":"Sterling","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition Department of Internal Medicine Virginia Commonwealth University Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryce B.","family":"Reeve","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Duke University Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol E.","family":"Golin","sequence":"additional","affiliation":[{"name":"Division of General Medicine and Clinical Epidemiology Department of Medicine Department of Health Behaviors University of North Carolina Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Rajender Reddy","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1126-8128","authenticated-orcid":false,"given":"Joseph K.","family":"Lim","sequence":"additional","affiliation":[{"name":"Digestive Diseases Department of Internal Medicine Yale 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