{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:48:16Z","timestamp":1786711696681,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>There is intense research for drugs able to reduce disease progression in nonalcoholic fatty liver disease. We aimed to test the impact of novel antidiabetic drugs (dipeptidyl\u2010peptidase\u20104 inhibitors \u2013 DPP\u20104Is, glucagon\u2010like peptide\u20101 receptor agonists \u2013 GLP\u20101RAs, sodium\u2010glucose cotransporter\u20102 inhibitors \u2013 SGLT\u20102Is) on non\u2010invasive biomarkers of steatosis (fatty liver index, FLI) and fibrosis (Fibrosis\u20104 score, FIB\u20104) in patients with type 2 diabetes (T2D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical, anthropometric and biochemical parameters were retrospectively analysed in 637 consecutive T2D patients switched from metformin w\/wo sulfonylureas and\/or pioglitazone to DPP\u20104Is, GLP\u20101RAs and SGLT\u20102Is in a tertiary care setting. 165 patients maintained on original treatments served as controls. The effects on FLI and FIB\u20104 at 6\u2010 and 12\u2010month follow\u2010up were analysed by logistic regression after adjustment for baseline differences, computed by propensity scores, and additional adjustment for changes in glycosylated hemoglobin (HbA1c) and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body mass index, HbA1c and aminotrasferases significantly decreased following switching to GLP\u20101RAs and SGLT2\u2010Is, compared with both controls and DPP\u20104Is, whereas only HbA1c was reduced on DPP\u20104Is. FLI and FIB\u20104 were reduced on GLP\u20101RA and SGLT\u20102I; logistic regression analysis confirmed a significant improvement of both biomarkers after adjustment for propensity score. The shift of FIB\u20104 values towards the category ruling out advanced fibrosis was maintained after additional adjustment for confounders. These effects were confirmed in a sensitivity analysis on effect size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Glucagon\u2010like peptide\u20101 receptor agonists and SGLT\u20102Is improve biomarkers of steatosis and fibrosis, in keeping with beneficial effects on liver disease progression, and should be considered the treatment of choice in T2D.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14799","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T15:25:31Z","timestamp":1611674731000},"page":"731-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Effects of antidiabetic agents on steatosis and fibrosis biomarkers in type 2 diabetes: A real\u2010world data 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